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  • 1
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    The transcriptional program of sporulation in budding yeast (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-10-23
    Description: Diploid cells of budding yeast produce haploid cells through the developmental program of sporulation, which consists of meiosis and spore morphogenesis. DNA microarrays containing nearly every yeast gene were used to assay changes in gene expression during sporulation. At least seven distinct temporal patterns of induction were observed. The transcription factor Ndt80 appeared to be important for induction of a large group of genes at the end of meiotic prophase. Consensus sequences known or proposed to be responsible for temporal regulation could be identified solely from analysis of sequences of coordinately expressed genes. The temporal expression pattern provided clues to potential functions of hundreds of previously uncharacterized genes, some of which have vertebrate homologs that may function during gametogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chu, S -- DeRisi, J -- Eisen, M -- Mulholland, J -- Botstein, D -- Brown, P O -- Herskowitz, I -- AI18738/AI/NIAID NIH HHS/ -- GH00450/GH/CGH CDC HHS/ -- GM46406/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1998 Oct 23;282(5389):699-705.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143-0448, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9784122" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosomes, Fungal/physiology ; *DNA-Binding Proteins ; Fungal Proteins/genetics/metabolism ; *Gene Expression Regulation, Fungal ; Genes, Fungal ; Genome, Fungal ; Humans ; Meiosis/*genetics ; Morphogenesis ; Organelles/ultrastructure ; Saccharomyces cerevisiae/*genetics/physiology ; *Saccharomyces cerevisiae Proteins ; Spores, Fungal/*genetics/physiology/ultrastructure ; Transcription Factors/genetics/metabolism ; *Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    A role for the protease falcipain 1 in host cell invasion by the human malaria parasite (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-12-10
    Description: Cysteine proteases of Plasmodium falciparum are required for survival of the malaria parasite, yet their specific cellular functions remain unclear. We used a chemical proteomic screen with a small-molecule probe to characterize the predominant cysteine proteases throughout the parasite life cycle. Only one protease, falcipain 1, was active during the invasive merozoite stage. Falcipain 1-specific inhibitors, identified by screening of chemical libraries, blocked parasite invasion of host erythrocytes, yet had no effect on normal parasite processes such as hemoglobin degradation. These results demonstrate a specific role for falcipain 1 in host cell invasion and establish a potential new target for antimalarial therapeutics.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Greenbaum, Doron C -- Baruch, Amos -- Grainger, Munira -- Bozdech, Zbynek -- Medzihradszky, Katlin F -- Engel, Juan -- DeRisi, Joseph -- Holder, Anthony A -- Bogyo, Matthew -- MC_U117532067/Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2002 Dec 6;298(5600):2002-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmaceutical Chemistry, Veterans Affairs Medical Center, University of California, San Francisco, CA 94143, USA. dgreenb@itsa.ucsf.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12471262" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cysteine Endopeptidases/isolation & purification/*metabolism ; Cysteine Proteinase Inhibitors/chemistry/pharmacology ; Dose-Response Relationship, Drug ; Erythrocytes/*parasitology ; Fluorescent Antibody Technique ; Hemoglobins/metabolism ; Humans ; Leucine/*analogs & derivatives/pharmacology ; Life Cycle Stages ; Organelles/enzymology ; Plasmodium falciparum/drug effects/*enzymology/growth & ; development/*pathogenicity ; Proteomics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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