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  • 1
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 17 (1981), S. 1835-1842 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A square tensile sheet with symmetric edge cracks is analysed by the finite element method to demonstrate the accuracy obtained with polynomial elements when the mesh patterns are chosen on the basis of the element's interpolation functions. Numerical results are provided for the accuracy of the total strain energy, the stress intensity factor, and the numerical condition of the global stiffness matrix. The stress intensity factor is determined to within 1.0 per cent accuracy using quadratic (linear strain) triangular elements with only 138 degrees-of-freedom.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 28 (1989), S. 127-144 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The successive quadratic programming (SQP) method is used with the finite element method (FEM) to solve frictionless geometrically non-linear contact problems involving large deformations of the elastica in the presence of flat rigid walls. To formulate the SQP problems, the potential energy (PE) is expanded in a Taylor series of second order in displacement increments about a configuration near a contact solution. The SQP problems consist of minimizing the Taylor expansion of the PE subject to the inequality constraints which represent contact. The quadratic programming (QP) method is made part of a Newton-Raphson (NR) search in which the QP corrections are made when a NR step does not satisfy the constraints. A revised simplex method developed by Rusin is used to solve the QP problems. The elastica is modelled with a total Lagrangian FEM developed by Fried. Solutions are obtained for the end loaded buckled elastica in point contact with a rigid wall and for a uniformly loaded elastica in regional contact with a rigid wall. The problems are also solved using a penalty method. The results obtained for the point contact problem are compared to an analytical solution. Calculations were made to obtain numerical information on maximum load step size and the number of inverse operations required for each load step. Cases in which the elastica stiffened substantially as a result of the initiation of contact are also discussed.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 9 (1989), S. 151-165 
    ISSN: 0271-2091
    Keywords: Numerical analysis ; Fluid flow ; Rotating circular duct ; Finite cell method ; Finite element method ; Swirl ; Inlet boundary conditions ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A numerical analysis of the flow pattern in the inlet region of a circular pipe rotating steadily about an axis parallel to its own is presented. Both finite cell and finite element methods are used to analyse the problem and they give qualitatively similar results which show that a swirling fluid motion is induced in the pipe inlet region. The analyses show that the direction of swirl is opposite to that of the pipe rotation when viewed along the flow axis and that its magnitude depends on the speed of pipe rotation and throughflow Reynolds number. Neither numerical analysis predicts the marked upturn in friction factor (or pressure drop) which has been observed experimentally. However, a dependence on the pipe inlet boundary conditions is demonstrated.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 23 (1996), S. 1241-1262 
    ISSN: 0271-2091
    Keywords: axisymmetric flow ; vortex method ; laminar flow ; entrance length ; steady and oscillating flows ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Steady and oscillating axisymmetric tube flows are modelled using a vorticity transport algorithm. The axisymmetric convective -diffusive Navier-Stokes equations are solved using a splitting technique. Axisymmetric ring vortex filaments are introduced on the walls and subsequently convected and diffused throughout the flow field. An axisymmetric equation similar to the Oseen diffusion equation is used to diffuse the ring vortex filaments. Vorticity is reflected from the tube walls using two techniques. Results are presented for the developing Poiseuille flow and for the developed flow in the form of the entrance length and the axial velocity and vorticity profiles. Good agreement is achieved with a finite difference method in the developing region of Poiseuille flow. The developed flow results are compared with the analytical solutions. The developed profiles of velocity and vorticity have errors of less than 0ċ3 per cent for both methods of dealing with reflection of diffusion at the bounding surfaces and similar accuracy is obtained for the velocity profiles in oscillating flow except at the wall. Oscillating flow is produced with a discretized sinusoidal piston motion. Velocity profiles, boundary layer thickness and entrance length are presented for oscillating flow. Good agreement is achieved for low-Womersley-number non-dimensional frequency. At higher values of this parameter, flows are inaccurately simulated, because the number of piston positions used to discretize the piston motion is inversely proportional to the non-dimensional frequency.
    Additional Material: 19 Ill.
    Type of Medium: Electronic Resource
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  • 5
    Publication Date: 2011-08-24
    Description: No abstract available
    Keywords: Life Sciences (General)
    Type: Polymer Prepr (ISSN 0032-3934); Volume 38; 2; 668-9
    Format: text
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  • 6
    Publication Date: 2011-08-24
    Description: One of the primary goals of the study of thirst is to understand why drinking occurs under ad libitum or natural conditions. An appreciation of the experimental strategies applied by physiologists studying thirst from different perspectives can facilitate progress toward understanding the natural history of drinking behavior. Drinking research carried out using three separate perspectives-homeostatic, circadian rhythms, and food-associated-generates types of information about the mechanisms underlying drinking behavior. By combining research strategies and methods derived from each of these approaches, it has been possible to gain new information that increases our appreciation of the interactions between homeostatic mechanisms and circadian rhythms in the modulation of water intake and how these might be related to drinking associated with food intake under near natural conditions.
    Keywords: Life Sciences (General)
    Type: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.] (ISSN 0100-879X); Volume 30; 4; 487-91
    Format: text
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  • 7
    Publication Date: 2011-08-24
    Description: In this study, we examined whether air-jet stress-induced active sympathetic hindlimb vasodilation in conscious rats involves the release of preformed stores of nitric oxide-containing factors. We determined the effects of repeated episodes of air-jet stress (six episodes given 5 minutes apart) on mean arterial pressure and vascular resistances in the mesenteric bed and intact and sympathetically denervated hindlimb beds of conscious rats treated with saline or the nitric oxide synthesis inhibitor N omega-nitro-L-arginine methyl ester (L-NAME, 25 mumol/kg IV). In saline-treated rats, air-jet stress produced alerting behavior, minor changes in blood pressure, pronounced mesenteric vaso-constriction, and immediate and marked vasodilation in the sympathetically intact hindlimb but a minor vasodilation in the sympathetically denervated hindlimb. Each air-jet stress produced virtually identical responses. In L-NAME-treated rats, the first air-jet stress produced vasodilator responses in the sympathetically intact and sympathetically denervated hindlimbs that were similar to those in the saline-treated rats. However, each subsequent air-jet stress produced progressively smaller vasodilator responses in the sympathetically intact but not the sympathetically denervated hindlimb. There was no loss of air-jet stress-induced alerting behavior or mesenteric vasoconstriction, suggesting that L-NAME did not interfere with the central processing of the air-jet or the resultant changes in autonomic nerve activity. The progressive diminution of air-jet stress-induced vasodilation in the intact hindlimb of L-NAME-treated rats may be due to the use-dependent depletion of preformed stores of nitric oxide-containing factors that cannot be replenished in the absence of nitric oxide synthesis.
    Keywords: Life Sciences (General)
    Type: Hypertension (ISSN 0194-911X); Volume 28; 3; 347-53
    Format: text
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  • 8
    Publication Date: 2011-08-24
    Description: For assessing health risk, the measurement of physical dose received during a space mission, as well as the LETs, energies and charges of particles is important. It is also important to obtain quantitative information regarding the effectiveness of space radiation in causing damage to critical biological targets, e.g., chromosomes, since at present the estimated uncertainty of biological effects of space radiation is more than a factor of two. Such large uncertainty makes accurate health risk assessment very difficult. For this very reason, a study on cytogenetic effects of space radiation in human lymphocytes was proposed and done for MIR-18 mission. This study used FISH technique to score chromosomal translocations and C-banding method to determine dicentrics. Growth kinetics of cells and SCE were examined to ensure that chromosomal aberrations were scored in first mitosis and were induced not by chemical mutagens. Our results showed that chromosomal aberration frequency of post-flight samples was significantly higher than that of pre-flight ones and that SCE frequency was similar between pre- and post-flight samples. Based on a dose-response curve of preflight samples exposed to gamma rays, the absorbed dose received by crews during the mission was estimated to be about 14.5 cSv. Because the absorbed dose measured by physical dosimeters is 4.16 cGy for the entire mission, the RBE is about 3.5.
    Keywords: Life Sciences (General)
    Type: Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine (ISSN 0233-528X); Volume 31; 2; 8-14
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  • 9
    Publication Date: 2011-08-24
    Description: Astronauts are classified as radiation workers due to the presence of ionizing radiation in space. For the assessment of health risks, physical dosimetry has been indispensable. However, the change of the location of dosimeters on the crew members, the variation in dose rate with location inside the spacecraft and the unknown biological effects of microgravity can introduce significant uncertainties in estimating exposure. To circumvent such uncertainty, a study on the cytogenetic effects of space radiation in human lymphocytes was proposed and conducted for Mir-18, a 115-day mission. This study used fluorescence in situ hybridization (FISH) with whole-chromosome painting probes to score chromosomal exchanges and the Giemsa staining method to determine the frequency of dicentrics. The growth kinetics of cells and sister chromatid exchanges (SCEs) were examined to ensure that chromosomal aberrations were scored in the first mitosis and were induced primarily by space radiation. Our results showed that the frequency of chromosomal aberrations increased significantly in postflight samples compared to samples drawn prior to flight, and that the frequency of SCEs was similar for both pre- and postflight samples. Based on a dose-response curve for preflight samples exposed to gamma rays, the absorbed dose received by crew members during the mission was estimated to be about 14.75 cSv. Because the absorbed dose measured by physical dosimeters is 5.2 cGy for the entire mission, the RBE is about 2.8.
    Keywords: Life Sciences (General)
    Type: Radiation research (ISSN 0033-7587); Volume 148; 5 Suppl; S17-23
    Format: text
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  • 10
    Publication Date: 2019-07-13
    Description: The expression of Fos protein (Fos immunoreactivity, Fos-ir) was mapped in the brain of rats subjected to an angiotensin-dependent model of thirst and salt appetite. The physiological state associated with water and sodium ingestion was produced by the concurrent subcutaneous administration of the diuretic furosemide (10 mg/kg) and a low dose of the angiotensin-converting enzyme (ACE) inhibitor captopril (5 mg/kg; Furo/Cap treatment). The animals were killed 2 h posttreatment, and the brains were processed for Fos-ir to assess neural activation. Furo/Cap treatment significantly increased Fos-ir density above baseline levels both in structures of the lamina terminalis and hypothalamus known to mediate the actions of ANG 2 and in hindbrain regions associated with blood volume and pressure regulation. Furo/Cap treatment also typically increased Fos-ir density in these structures above levels observed after administration of furosemide or captopril separately. Fos-ir was reduced to a greater extent in forebrain than in hindbrain areas by a dose of captopril (100 mg/kg sc) known to block the actions of ACE in the brain. The present work provides further evidence that areas of lamina terminalis subserve angiotensin-dependent thirst and salt appetite.
    Keywords: Life Sciences (General)
    Type: American Journal of Physiology (ISSN 0363-6119); 74; R1807-1814
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