ISSN:
1572-879X
Keywords:
Enantioselective hydrogenation
;
rhodium complex
;
chiral cationic phosphine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Rhodium complexes of the chiral cationic phosphine, (S,S)-2,4-bis[bis-(p-N,N.N-trimethyl-ammoniumphenyl)phosphino]pentane show excellent enantioselectivity for the hydrogenation of the DOPA precursor. (Z)-3-OMe,4-OAcC6H3CHC(COOH)(NHCOCH3), and dehydro-phenylalanineacetamide as slurries in water. The catalytic reactions may be done in either a two-phase system with the catalyst in the aqueous phase or as a slurry in water provided the substrates have some water solubility. Enantioselectivities of as high as 95% can be obtained.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00763951
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