Publication Date:
2001-09-08
Description:
Bcl-2 family members bearing only the BH3 domain are essential inducers of apoptosis. We identified a BH3-only protein, Bmf, and show that its BH3 domain is required both for binding to prosurvival Bcl-2 proteins and for triggering apoptosis. In healthy cells, Bmf is sequestered to myosin V motors by association with dynein light chain 2. Certain damage signals, such as loss of cell attachment (anoikis), unleash Bmf, allowing it to translocate and bind prosurvival Bcl-2 proteins. Thus, at least two mammalian BH3-only proteins, Bmf and Bim, function to sense intracellular damage by their localization to distinct cytoskeletal structures.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Puthalakath, H -- Villunger, A -- O'Reilly, L A -- Beaumont, J G -- Coultas, L -- Cheney, R E -- Huang, D C -- Strasser, A -- CA 80188/CA/NCI NIH HHS/ -- R29 DC003299/DC/NIDCD NIH HHS/ -- New York, N.Y. -- Science. 2001 Sep 7;293(5536):1829-32.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Walter and Eliza Hall Institute of Medical Research, Melbourne, P.O. Royal Melbourne Hospital, 3050 VIC, Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11546872" target="_blank"〉PubMed〈/a〉
Keywords:
*Adaptor Proteins, Signal Transducing
;
Amino Acid Sequence
;
Animals
;
*Anoikis
;
Apoptosis Regulatory Proteins
;
Calmodulin-Binding Proteins/*metabolism
;
Carrier Proteins/*chemistry/genetics/*metabolism
;
Cell Line
;
Cytoskeleton/metabolism
;
*Drosophila Proteins
;
Dyneins
;
Gene Expression Profiling
;
Humans
;
*Membrane Proteins
;
Mice
;
Molecular Motor Proteins/*metabolism
;
Molecular Sequence Data
;
Mutation
;
Myeloid Cell Leukemia Sequence 1 Protein
;
*Myosin Type V
;
Neoplasm Proteins/genetics/metabolism
;
Nerve Tissue Proteins/*metabolism
;
Protein Binding
;
Protein Structure, Tertiary
;
Protein Transport
;
*Proto-Oncogene Proteins
;
Proto-Oncogene Proteins c-bcl-2/chemistry/genetics/metabolism
;
RNA, Messenger/analysis/genetics
;
Transfection
;
Two-Hybrid System Techniques
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink