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  • 1
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    Mimicry of CD40 signals by Epstein-Barr virus LMP1 in B lymphocyte responses (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-10-09
    Description: The effect of the Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) on the activation and differentiation of normal B cells was investigated. B cells of transgenic mice expressing LMP1 under the control of immunoglobulin promoter/enhancer displayed enhanced expression of activation antigens and spontaneously proliferated and produced antibody. Humoral immune responses of LMP1 transgenic mice in CD40-deficient or normal backgrounds revealed that LMP1 mimics CD40 signals to induce extrafollicular B cell differentiation but, unlike CD40, blocks germinal center formation. Thus, these specific properties of LMP1 may determine the site of primary B cell infection and the state of infection in the natural course of EBV infection, whereas subsequent loss of LMP1 expression may affect the site of persistent latent infection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Uchida, J -- Yasui, T -- Takaoka-Shichijo, Y -- Muraoka, M -- Kulwichit, W -- Raab-Traub, N -- Kikutani, H -- CA19014/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1999 Oct 8;286(5438):300-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10514374" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibody Affinity ; Antigens, CD40/genetics/*metabolism ; B-Lymphocytes/*immunology/metabolism/virology ; Cell Differentiation ; Female ; Germinal Center/immunology/metabolism ; Herpesvirus 4, Human/*metabolism/physiology ; Immunization ; Immunoglobulin Class Switching ; Immunoglobulins/biosynthesis ; Interleukin-4/pharmacology ; *Lymphocyte Activation ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; *Molecular Mimicry ; NF-kappa B/metabolism ; Signal Transduction ; Spleen/immunology ; Viral Matrix Proteins/genetics/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Vortex lattice structure in BaFe2(As0.67P0.33)2 via small-angle neutron scattering (2014)
    American Physical Society (APS)
    Details
    Publication Date: 2014-09-10
    Description: Author(s): R. Morisaki-Ishii, H. Kawano-Furukawa, A. S. Cameron, L. Lemberger, E. Blackburn, A. T. Holmes, E. M. Forgan, L. M. DeBeer-Schmitt, K. Littrell, M. Nakajima, K. Kihou, C. H. Lee, A. Iyo, H. Eisaki, S. Uchida, J. S. White, C. D. Dewhurst, J. L. Gavilano, and M. Zolliker We have observed a magnetic vortex lattice (VL) in BaFe2(As0.67P0.33)2 (BFAP) single crystals by small-angle neutron scattering. With the field along the c axis, a nearly isotropic hexagonal VL was formed in the field range from 1 to 16 T, and no symmetry changes in the VL were observed. The tempera... [Phys. Rev. B 90, 125116] Published Tue Sep 09, 2014
    Keywords: Electronic structure and strongly correlated systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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