ISSN:
1476-5535
Keywords:
biotransformation
;
N-heptyl physostigmine
;
cholinesterase inhibitors
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Process Engineering, Biotechnology, Nutrition Technology
Notes:
Abstract The microbiological transformation ofN-heptyl physostigmine (L-693, 487) (1), a semisynthetic physostigmine cholinesterase inhibitor, was investigated usingVerticillium lecanii MF 5713 (ATCC 74148),Acremonium sp MF 5723 (ATCC 74164) andActinoplanes sp MA 6559 (ATCC 53771). Nine microbial metabolites (2–10) of 1 were isolated and purified using reversed-phase HPLC. The structures of the metabolites were established using spectroscopic techniques including MS and NMR. Some of the microbial metabolites were identical to metabolites present in urine of a dog treated with 1.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01569808
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