Publication Date:
2004-10-16
Description:
Long-term memory is thought to be mediated by protein synthesis-dependent, late-phase long-term potentiation (L-LTP). Two secretory proteins, tissue plasminogen activator (tPA) and brain-derived neurotrophic factor (BDNF), have been implicated in this process, but their relationship is unclear. Here we report that tPA, by activating the extracellular protease plasmin, converts the precursor proBDNF to the mature BDNF (mBDNF), and that such conversion is critical for L-LTP expression in mouse hippocampus. Moreover, application of mBDNF is sufficient to rescue L-LTP when protein synthesis is inhibited, which suggests that mBDNF is a key protein synthesis product for L-LTP expression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pang, Petti T -- Teng, Henry K -- Zaitsev, Eugene -- Woo, Newton T -- Sakata, Kazuko -- Zhen, Shushuang -- Teng, Kenneth K -- Yung, Wing-Ho -- Hempstead, Barbara L -- Lu, Bai -- NS30658/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2004 Oct 15;306(5695):487-91.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Section on Neural Development and Plasticity, Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development (NICHD), Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15486301" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Anisomycin/pharmacology
;
Brain-Derived Neurotrophic Factor/*metabolism/pharmacology
;
Electric Stimulation
;
Excitatory Postsynaptic Potentials
;
Fibrinolysin/*metabolism
;
Hippocampus/*physiology
;
In Vitro Techniques
;
*Long-Term Potentiation
;
Male
;
Mice
;
Mice, Knockout
;
Precipitin Tests
;
Protein Precursors/metabolism
;
Protein Synthesis Inhibitors/pharmacology
;
Synapses/*metabolism
;
Synaptic Transmission
;
Tissue Plasminogen Activator/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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