Publication Date:
1988-03-25
Description:
The elastin receptor complex contains a component of 67 kilodaltons that binds to a glycoconjugate affinity column containing beta-galactoside residues and is eluted from this column with lactose. This protein component is also released from the surface of cultured chondroblasts by incubation with lactose, and its association with immobilized elastin is inhibited by lactose. Since lactose also blocks elastic fiber formation by cultured chondroblasts, the galactoside-binding property of the elastin receptor is implicated in this process.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hinek, A -- Wrenn, D S -- Mecham, R P -- Barondes, S H -- HL-26499/HL/NHLBI NIH HHS/ -- HL-29594/HL/NHLBI NIH HHS/ -- HL-38627/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1988 Mar 25;239(4847):1539-41.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology and Physiology, Jewish Hospital, Washington University Medical Center, St. Louis, MO 63110.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2832941" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cartilage/analysis
;
Cattle
;
Cells, Cultured
;
Chromatography, Affinity
;
Elastin/metabolism
;
Extracellular Matrix/drug effects/metabolism
;
Galactosides/*metabolism
;
Glycoconjugates/metabolism
;
Glycosides/*metabolism
;
Immunoassay
;
Immunohistochemistry
;
Lactose/pharmacology
;
Lung/*analysis
;
Microscopy, Electron
;
Receptors, Cell Surface/drug effects/isolation & purification/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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