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  • 1
    Electronic Resource
    Electronic Resource
    Increased risk of ischaemic heart disease mortality in elderly men using anxiolytics-hypnotics and analgesics (1996)
    Springer
    European journal of clinical pharmacology 49 (1996), S. 261-265 
    Details
    ISSN: 1432-1041
    Keywords: Cardiovascular mortality ; Anxiolyticshypnotics ; pharmacoepidemiology ; adverse drug effect ; cohort study ; benzodiazepines ; analgesics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objectives: An increased risk of all-cause and cardiovascular mortality in users of anxiolytic-hypnotic drugs (AHD) has been reported, and use of analgesics may be an additional factor. Therefore, we examined the association of AHD and analgesic use, alone and in combination, with all-cause and ischaemic heart disease (IHD) mortality. Methods: Multivariate 10-year survival analysis in a population based cohort of 500 men born in 1914. Relative risks (RR) were adjusted by relevant confounders (blood pressure, serum cholesterol, diabetes mellitus, smoking habit, high alcohol consumption, history of previous IHD, cancer, and other diseases). Results: The RR of both all-cause and IHD mortality were significantly increased among those using both AHD and analgesics compared to those who took neither of these drugs: RR=1.8 for all-cause mortality, and RR=2.7 for IHD mortality. Conclusion: Although the number of cases was small, warranting interpretative caution, the current study suggests that the combined use of AHD (mainly benzodiazepines) and analgesics seems to be associated with an increase in all-cause and IHD mortality in elderly men.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00226325
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  • 2
    Electronic Resource
    Electronic Resource
    Intra-urban variation of antibiotic utilization in children: influence of socio-economic factors (1998)
    Springer
    European journal of clinical pharmacology 54 (1998), S. 653-657 
    Details
    ISSN: 1432-1041
    Keywords: Key words Antibiotic utilization ; Intra-urban variation ; Children ; Socio-economic ; Ecological
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: The aim of this study was to investigate the intra-urban variation of antibiotic utilization in children in Malmö and to evaluate the influence of socio-economic factors on this variation. Methods: In an ecological analysis, the variations in antibiotic utilization in children, expressed as defined daily dose (DDD) or as the number of prescriptions per 1000 inhabitants per day, were compared with variations in socio-economic and demographic factors in the 17 administrative districts of the Swedish city of Malmö (235 000 inhabitants). Results: There were large between-area differences in antibiotic utilization, especially in children aged 0–6 years. Socio-economic factors reflecting a privileged situation correlated positively with antibiotic utilization. Thus, in districts with a high median family income and a high employment rate, the utilization of antibiotics was higher than in other districts. Conversely, in districts with a high proportion of blue-collar workers, people with foreign backgrounds and recipients of social benefit, antibiotic utilization was comparatively low. In contrast, the utilization of penicillin V relative to other antibiotics showed an opposite pattern, including positive correlations with the proportion of social benefit, immigrants and blue-collar workers and a negative correlation with employment rate. Conversely, the utilization of macrolides in relation to other antibiotics in children aged 0–6 years was highest in districts inhabited by those who were socio-economically privileged. Interpretation: The findings suggest that utilization of antibiotics in children may vary considerably within a city, that it may increase with the degree of parental affluence, and that such affluence may reduce the utilization of penicillin V relative to other antibiotics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050529
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Increased risk of ischaemic heart disease mortality in elderly men using anxiolytics-hypnotics and analgesics Results of the 10-year follow-up of the prospective population study “Men born in 1914”, Malmö, Sweden (1996)
    Springer
    European journal of clinical pharmacology 49 (1996), S. 261-265 
    Details
    ISSN: 1432-1041
    Keywords: Key words Cardiovascular mortality ; Anxiolytics-hypnotics; pharmacoepidemiology ; adverse drug effect ; cohort study ; benzodiazepines ; analgesics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract. Objectives: An increased risk of all-cause and cardiovascular mortality in users of anxiolytic-hypnotic drugs (AHD) has been reported, and use of analgesics may be an additional factor. Therefore, we examined the association of AHD and analgesic use, alone and in combination, with all-cause and ischaemic heart disease (IHD) mortality. Methods: Multivariate 10-year survival analysis in a population based cohort of 500 men born in 1914. Relative risks (RR) were adjusted by relevant confounders (blood pressure, serum cholesterol, diabetes mellitus, smoking habit, high alcohol consumption, history of previous IHD, cancer, and other diseases). Results: The RR of both all-cause and IHD mortality were significantly increased among those using both AHD and analgesics compared to those who took neither of these drugs: RR = 1.8 for all-cause mortality, and RR = 2.7 for IHD mortality. Conclusion: Although the number of cases was small, warranting interpretative caution, the current study suggests that the combined use of AHD (mainly benzodiazepines) and analgesics seems to be associated with an increase in all-cause and IHD mortality in elderly men.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00226325
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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