Publication Date:
2015-08-08
Description:
The latest Ebola virus (EBOV) epidemic spread rapidly through Guinea, Sierra Leone, and Liberia, creating a global public health crisis and accelerating the assessment of experimental therapeutics and vaccines in clinical trials. One of those vaccines is based on recombinant vesicular stomatitis virus expressing the EBOV glycoprotein (VSV-EBOV), a live-attenuated vector with marked preclinical efficacy. Here, we provide the preclinical proof that VSV-EBOV completely protects macaques against lethal challenge with the West African EBOV-Makona strain. Complete and partial protection was achieved with a single dose given as late as 7 and 3 days before challenge, respectively. This indicates that VSV-EBOV may protect humans against EBOV infections in West Africa with relatively short time to immunity, promoting its use for immediate public health responses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marzi, Andrea -- Robertson, Shelly J -- Haddock, Elaine -- Feldmann, Friederike -- Hanley, Patrick W -- Scott, Dana P -- Strong, James E -- Kobinger, Gary -- Best, Sonja M -- Feldmann, Heinz -- Intramural NIH HHS/ -- New York, N.Y. -- Science. 2015 Aug 14;349(6249):739-42. doi: 10.1126/science.aab3920. Epub 2015 Aug 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. ; Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. ; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada. ; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. feldmannh@niaid.nih.gov.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26249231" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Drug Evaluation, Preclinical
;
Ebola Vaccines/*administration & dosage/immunology
;
Ebolavirus/genetics/*immunology
;
Genetic Vectors
;
Glycoproteins/genetics/*immunology
;
Hemorrhagic Fever, Ebola/*prevention & control
;
Macaca
;
Vesiculovirus
;
Viral Proteins/genetics/*immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
