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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular neurobiology 7 (1987), S. 255-269 
    ISSN: 1573-6830
    Keywords: phorbol dibutyrate ; M current ; muscarine ; ganglion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. Effects of bath-applied phorbol dibutyrate (PDBu) on M currents (I M) and on the inhibition ofI M by muscarine and luteinizing hormone-releasing hormone (LHRH) were recorded in voltage-clamped bullfrog lumbar sympathetic ganglion cells. 2. PDBu (0.1–30µM) produced a slowly developing, irreversible and partial (⩽60%) inhibition ofI M. This effect was not replicated by 4-α-phorbol or by vehicle. 3. After treatment with PDBu, residualI M showed a reduced sensitivity to inhibition by muscarine or LHRH but not by Ba2+. The reduced response to muscarine appeared to result from a 10-fold shift in the concentration dependence for inhibition. 4. PDBu did not clearly reproduce the ability of muscarine to inhibit the slow, Ca-activated K currentI AHP or to increase the leak conductance at hyperpolarized potentials. The latter effect of muscarine was enhanced, rather than inhibited, by PDBu. 5. I M andI AHP were not inhibited by 1 mM dibutyryl cyclic AMP or by 20µM forskolin. 6. It is concluded that activation of protein kinase C, but not protein kinase A, partly replicates the effect of muscarine on frog sympathetic neurons.
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 2019-08-17
    Description: In May 1999, the airborne thermal infrared hyperspectral imaging system, Spatially Enhanced Broadband Array Spectrograph System (SEBASS), was flown over Mon-non Mesa, NV, to provide the first test of such a system for geological mapping. Several types of carbonate deposits were identified using the 11.25 microns band. However, massive calcrete outcrops exhibited weak spectral contrast, which was confirmed by field and laboratory measurements. Because the weathered calcrete surface appeared relatively smooth in hand specimen, this weak spectral contrast was unexpected. Here we show that microscopic roughness not readily apparent to the eye has introduced both a cavity effect and volume scattering to reduce spectral contrast. The macroroughness of crevices and cobbles may also have a significant cavity effect. The diminished spectral contrast is important because it places higher signal-to-noise ratio (SNR) requirements for spectroscopic detection and identification. This effect should be factored into instrumentation planning and interpretations, especially interpretations without benefit of ground truth. SEBASS had the required high SNR and spectral resolution to allow us to demonstrate for the first time the ability of an airborne hyperspectral thermal infrared scanner to detect and identify spectrally subtle materials.
    Keywords: Earth Resources and Remote Sensing
    Type: Remote Sensing of Evironment (ISSN 0034-4257); 80; 447-459
    Format: application/pdf
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