ALBERT

Description: Color Doppler images of aortic regurgitation (AR) flow acceleration, flow convergence (FC), and the vena contracta (VC) have been reported to be useful for evaluating severity of AR. However, clinical application of these methods has been limited because of the difficulty in clearly imaging the FC and VC. This study aimed to explore new windows for imaging the FC and VC to evaluate AR volumes in patients and to validate this in animals with chronic AR. Forty patients with AR and 17 hemodynamic states in 4 sheep with strictly quantified AR volumes were evaluated. A Toshiba SSH 380A with a 3.75-MHz transducer was used to image the FC and VC. After routine echo Doppler imaging, patients were repositioned in the right lateral decubitus position, and the FC and VC were imaged from high right parasternal windows. In only 15 of the 40 patients was it possible to image clearly and measure accurately the FC and VC from conventional (left decubitus) apical or parasternal views. In contrast, 31 of 40 patients had clearly imaged FC regions and VCs using the new windows. In patients, AR volumes derived from the FC and VC methods combined with continuous velocity agreed well with each other (r = 0.97, mean difference = -7.9 ml +/- 9.9 ml/beat). In chronic animal model studies, AR volumes derived from both the VC and the FC agreed well with the electromagnetically derived AR volumes (r = 0.92, mean difference = -1.3 +/- 4.0 ml/beat). By imaging from high right parasternal windows in the right decubitus position, complementary use of the FC and VC methods can provide clinically valuable information about AR volumes.

Description: We present a review of converging sources of evidence which suggest that the differences between loading histories experienced in 1-g and weightlessness are sufficient to stimulate adaptation in mechanical impedance of the musculoskeletal system. As a consequence of this adaptive change we argue that we should observe changes in the ability to attenuate force transmission through the musculoskeletal system both during and after space flight. By focusing attention on the relation between human sensorimotor activity and support surfaces, the importance of controlling mechanical energy flow through the musculoskeletal system is demonstrated. The implications of such control are discussed in light of visual-vestibular function in the specific context of head and gaze control during postflight locomotion. Evidence from locomotory biomechanics, visual-vestibular function, ergonomic evaluations of human vibration, and specific investigations of locomotion and head and gaze control after space flight, is considered.

Description: Beginning in 1989, the active phase of the present solar cycle became manifest in the outer heliosphere as large disturbances in solar wind velocity as observed by the Ames plasma analyzers aboard Pioneer 10 (46-50 AU heliocentric distance) and Pioneer 11 (about 28 AU). Inner heliospheric baseline plasma observations from the Pioneer Venus Orbiter (0.7 AU) and IMP 8 (1 AU) are useful for attempts to correlate solar events with the outer heliospheric disturbances. With regard to the onset of activity at Pioneer 11, Pioneer Venus observations are pertinent, and some of these in turn correspond with CMEs (coronal mass ejections) observed in SMM coronagraph data. In particular, enhanced solar wind speeds observed at Pioneer Venus during December 1988 to February 1989 are associated with seven large solar wind shocks (or shock candidates); corresponding CMEs may be identified. Two of these seven shocks were identified as candidates for a precursor to the onset of the disturbances at Pioneer 11. At Pioneer 10 the disturbed period includes two large disturbances, associated with the passage of shocks. There are several candidate CMEs in the SMM observations, one of which may be associated with the second Pioneer 10 shock.

Description: Astronauts adopt a variety of neuromuscular control strategies during space flight that are appropriate for locomoting in that unique environment, but are less than optimal upon return to Earth. We report here the first systematic investigation of potential adaptations in neuromuscular activity patterns associated with postflight locomotion. Astronaut-subjects were tasked with walking on a treadmill at 6.4 km/h while fixating a visual target 30 cm away from their eyes after space flights of 8-15 days. Surface electromyography was collected from selected lower limb muscles and normalized with regard to mean amplitude and temporal relation to heel strike. In general, high correlations (more than 0.80) were found between preflight and postflight activation waveforms for each muscle and each subject: however relative activation amplitude around heel strike and toe off was changed as a result of flight. The level of muscle cocontraction and activation variability, and the relationship between the phasic characteristics of the ankle musculature in preparation for toe off also were altered by space flight. Subjects also reported oscillopsia during treadmill walking after flight. These findings indicate that, after space flight, the sensory-motor system can generate neuromuscular-activation strategies that permit treadmill walking, but subtle changes in lower-limb neuromuscular activation are present that may contribute to increased lower limb kinematic variability and oscillopsia also present during postflight walking.

Description: This report is the first systematic evaluation of the effects of prolonged weightlessness on the bipedal postural control processes during self-generated perturbations produced by voluntary upper limb movements. Spaceflight impacts humans in a variety of ways, one of which is compromised postflight postural control. We examined the neuromuscular activation characteristics and center of pressure (COP) motion associated with arm movement of eight subjects who experienced long-duration spaceflight (3--6 mo) aboard the Mir space station. Surface electromyography, arm acceleration, and COP motion were collected while astronauts performed rapid unilateral shoulder flexions before and after spaceflight. Subjects generally displayed compromised postural control after flight, as evidenced by modified COP peak-to-peak anterior-posterior and mediolateral excursion, and pathlength relative to preflight values. These changes were associated with disrupted neuromuscular activation characteristics, particularly after the completion of arm acceleration (i.e., when subjects were attempting to maintain upright posture in response to self-generated perturbations). These findings suggest that, although the subjects were able to assemble coordination modes that enabled them to generate rapid arm movements, the subtle control necessary to maintain bipedal equilibrium evident in their preflight performance is compromised after long-duration spaceflight.

Description: The properties of the large-scale global merged interaction region (GMIR) generated by the intense solar events of March and June 1991 are studied using the available solar wind, interplanetary magnetic field, and energetic particle data from the observing network of Pioneer 10 and Voyagers 1 and 2 in the outer heliosphere. At heliocentric distances extending to 55 AU the delayed effects of this enhanced solar activity are observed in the form of large inceases in the solar wind velocity and interplanetary magnetic field and significant decreases in the galactic cosmic ray intensity. For low-energy ions (5-MeV protons) there was a single long-lived event extending over a period of some 6 months. Near the strongest interplanetary disturbances the H and He spectra are best represented by similar exponentials in momentum/nucleon (i.e., particle velocity at these at these energies). Over the rest of the event the characteristic momentum for He, (P(sub 0))(sub He) is generally approximately 0.66 for hydrogen. These spectra and the consistently low H/He ratio (25.3) at 2 MeV/nucleon closely resemble that observed in corrotating interaction regions events. Despite the strong north/south asymmetry in the solar activity, the interplanetary disturbances produced the same net decrease in the galactic cosmic ray intensity of ions greater than 70 MeV at the three widely separated spacecraft when the effects of the long-term recovery are taken into account. A comparison of the relative intensity of MeV ions at these three spacecraft suggest that the most intense solar events occurred on the back side of the Sun in time periods adjacent to the March and June episodes of solar activity. It is argued that this GMIR as a system is responsible for the low-frequency radio emission observed by the Voyager Plasma Wave experiment some 1.46 years after the onset of the March 1991 activity.

Description: A statistical study of the initial phases of a large number of solar particle events provides an approach for an investigation of the variability in the production process and coronal diffusion. A description is given of the procedures which are suitable for identifying the parent flare of an event, taking into account the heliocentric distribution of the flare-associated events. The determination of the proton energy spectrum at the sun is discussed along with the variation of the spectral index with the associated flare heliocentric longitude, questions concerning the source spectra and the acceleration process, and the size distribution of flare associated particle events.

Description: Landscape freeze/thaw transitions coincide with marked shifts in albedo, surface energy and mass exchange, and associated snow dynamics. monitoring landscape freeze/thaw dynamics would improve our ability to quantify the interannual variability of boreal hydrology and river runoff/flood dynamics, The annual duration of frost-free period also bounds the period of photosynthetic activity in borel and arctic regions thus affecting the carbon budget and the interannual variability fo regional carbon fluxes.

Description: The relative abundances of 1.5-23 MeV per nucleon ions in corotating nucleon streams are compared with ion abundances in particle events associated with solar flares and with solar and solar wind abundances. He/O and C/O ratios are found to be a factor of the order 2-3 greater in corotating streams than in flare-associated events. The distribution of H/He ratios in corotating streams is found to be much narrower and of lower average value than in flare-associated events. H/He in corotating energetic particle streams compares favorably in both lack of variability and numerical value with H/He in high-speed solar wind plasma streams. The lack of variability suggests that the source population for the corotating energetic particles is the solar wind, a suggestion consistent with acceleration of the corotating particles in interplanetary space.