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  • EPR spectroscopy  (1)
  • Nitroamphetamine  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Scavenging of the One-Electron Reduction Product from Nisoldipine with Relevant Thiols: Electrochemical and EPR Spectroscopic Evidences (1998)
    Springer
    Pharmaceutical research 15 (1998), S. 1690-1695 
    Details
    ISSN: 1573-904X
    Keywords: nitro radical anion ; nisoldipine ; cyclic voltammetry ; EPR spectroscopy ; thiol ; scavenging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Purpose. To determine the formation of the one-electron reduction product from nisoldipine and its reactivity with relevant thiols in mixed medium. Methods. Cyclic voltammetry (CV) and electron paramagnetic resonance (EPR) techniques were used to determine the one-electron reduction product corresponding to the nitro radical anion. CV was employed to assess both the rate constants corresponding to the decay of the radicals and its interaction with relevant thiols. Results. The nisoldipine radical anion follows second order kinetics, with an association rate constant of 283 ± 161mol−1 sec−1.Nitro radical anion from nisoldipine significantly reacted with thiol compounds. This reactivity was significantly higher than the natural decay of the radical in mixed medium. EPR spectra recordedin situ using DMF/ 0.1 N NaOH (pH 13) confirmed the formation of the nitro radical anion, giving a well-resolved spectra in 35 lines using 0.1 G modulation. Conclusions. Electrochemical and EPR data indicated that all the tested thiols scavenged the nitro radical anion from nisoldipine. The following tentative order of reactivity towards the thiols can be proposed: cysteamine ∼ glutathione 〉N-acetylcysteine 〉captopril 〉penicillamine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1011948410183
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  • 2
    Electronic Resource
    Electronic Resource
    Nitro radical anion formation from nitro-substituted amphetamine derivatives (1994)
    Weinheim : Wiley-Blackwell
    Electroanalysis 6 (1994), S. 509-513 
    Details
    ISSN: 1040-0397
    Keywords: Cyclic voltammetry ; Radical anion ; Nitroamphetamine ; Half-life time ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The cyclic voltammetric characteristics of two nitroamphetamine derivatives (2-nitro-4,5-dimethoxyamphetamine and 2-nitro-4,5-methylenedioxyamphetamine) have been investigated in different media. In mixed media (aqueous buffer and DMF, dioxane, or acetonitrile) a reversible one-electron reduction takes place to form a stable nitro radical anion. At more negative potential values, a further three-electron reduction occurs irreversibly to give the hydroxylamine derivative. Cyclic voltammetry (CV) has been employed to study the tendency of the nitro radical anions to undergo further chemical reactions. The subsequent chemical reaction corresponds to a second-order process, a dismutation reaction electrochemically initiated. Data about rate constants and half-life times in mixed media are reported.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elan.1140060525
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