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  • EEG  (1)
  • Na-H exchange  (1)
  • acidosis  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Molecular and cellular biochemistry 89 (1989), S. 157-162 
    ISSN: 1573-4919
    Keywords: acidosis ; contractility ; Na-H exchange ; cardiac muscle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Intracellular pH (pHi) and Na (ana i) were recorded in isolated sheep cardiac Purkinje fibres using ion-selective microelectrodes while simultaneously recording twitch tension. A fall of (pHi) stimulated acid-extrusion via sarcolemmal Na-H exchange but the extrusion was inhibited by reducing extracellular pH (pHo), indicating an inhibitory effect of external H ions upon the exchanger. Intracellular acidosis can reduce contraction by directly reducing myofibrillar Ca2− sensitivity. The activation of Na-H exchange at low (pHi) can offset this direct inhibitory effect of H− ions since exchange-activation elevates ana i which then indirectly elevates Cai 2+ (via Na-Ca exchange) thus tending to restore tension. This protection of contraction during intracellular acidosis can be removed if extracellular (pHi) is also allowed to fall since, under these conditions, Na-H exchange is inhibited.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Medical & biological engineering & computing 27 (1989), S. 365-370 
    ISSN: 1741-0444
    Keywords: EEG ; Epileptiform activity ; Expert system ; Production system ; Spike detection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract An expert system for the automated detection of spikes and sharp waves in the EEG has been developed. The system consists of two distinct stages. The first is a feature extractor, written in the conventional procedural language Fortran, which uses parts of previously published spike-detection, algorithms to produce a list of all spike-like occurrences in the EEG. The second stage, written in the production system language OPS5, reads the list and uses rules incorporating knowledge elicited from an electroencephalographer (EEGer) to confirm or exclude each of the possible spikes. Information such as the time of occurrence, polarity and channel relationship are used in this process. A summary of thedetected epileptiform events is produced which is available to the EEGer in interpreting the EEG. The performance of the expert system is compared with an EEGer using a 320s segment from an EEG containing epileptiform activity. The system detected 19 events and missed seven (false negative) which the EEGer considered epileptiform. There were no false positive detections.
    Type of Medium: Electronic Resource
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