Publication Date:
1979-10-26
Description:
Twenty opioids have been subdivided into four classes by using flurothyl-induced seizures in rats to measure dose-response relationships, stereospecificity, naloxone sensitivity, and tolerance-cross-tolerance. The data support current theories of multiple opiate receptor types. Since the receptors involved mediate effects that are antagonized, enhanced, or unaffected by naloxone, the model is uniquely suitable for detecting novel narcotic antagonists that can then be used to differentiate opiate receptors in other systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cowan, A -- Geller, E B -- Adler, M W -- New York, N.Y. -- Science. 1979 Oct 26;206(4417):465-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/504986" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Drug Tolerance
;
Flurothyl/antagonists & inhibitors
;
Male
;
Meperidine/classification/pharmacology
;
Naloxone/pharmacology
;
Narcotics/*classification/pharmacology
;
Pentazocine/classification/pharmacology
;
Rats
;
Seizures/chemically induced
;
Stereoisomerism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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