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  • 1
    Publication Date: 2008-03-18
    Description: Olfactory signals are transduced by a large family of odorant receptor proteins, each of which corresponds to a unique glomerulus in the first olfactory relay of the brain. Crosstalk between glomeruli has been proposed to be important in olfactory processing, but it is not clear how these interactions shape the odour responses of second-order neurons. In the Drosophila antennal lobe (a region analogous to the vertebrate olfactory bulb), we selectively removed most interglomerular input to genetically identified second-order olfactory neurons. Here we show that this broadens the odour tuning of these neurons, implying that interglomerular inhibition dominates over interglomerular excitation. The strength of this inhibitory signal scales with total feedforward input to the entire antennal lobe, and has similar tuning in different glomeruli. A substantial portion of this interglomerular inhibition acts at a presynaptic locus, and our results imply that this is mediated by both ionotropic and metabotropic receptors on the same nerve terminal.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824883/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824883/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Olsen, Shawn R -- Wilson, Rachel I -- R01 DC008174/DC/NIDCD NIH HHS/ -- R01 DC008174-03/DC/NIDCD NIH HHS/ -- England -- Nature. 2008 Apr 24;452(7190):956-60. doi: 10.1038/nature06864. Epub 2008 Mar 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18344978" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Drosophila melanogaster/*physiology ; Excitatory Postsynaptic Potentials/drug effects ; GABA-B Receptor Antagonists ; Neurons/drug effects/metabolism ; Odors/analysis ; Olfactory Pathways/drug effects/*physiology ; Patch-Clamp Techniques ; Physical Stimulation ; Presynaptic Terminals/drug effects/*physiology ; Receptors, GABA-B/metabolism ; Smell/drug effects/physiology ; gamma-Aminobutyric Acid/metabolism/pharmacology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 2
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2007-10-27
    Description: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838400/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838400/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wilson, Rachel I -- R01 DC008174/DC/NIDCD NIH HHS/ -- R01 DC008174-02/DC/NIDCD NIH HHS/ -- New York, N.Y. -- Science. 2007 Oct 26;318(5850):584-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. rachel_wilson@hms.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17962548" target="_blank"〉PubMed〈/a〉
    Keywords: *Acetates ; Animals ; Awards and Prizes ; Drosophila melanogaster/*physiology ; Electrophysiology ; Neurons/*physiology ; Odors ; *Oleic Acids ; Olfactory Pathways/*physiology ; Olfactory Receptor Neurons/*physiology ; *Pheromones ; Sense Organs/physiology ; Synapses/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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