Publication Date:
1984-04-27
Description:
Exogenous cholecystokinin selectively antagonizes opiate analgesia, which suggests that endogenous cholecystokinin may act physiologically as an opiate antagonist and may play a role in opiate tolerance. The use of the selective cholecystokinin antagonist proglumide provided a test of these hypotheses in rats that were either inexperienced with or tolerant to opiates. Proglumide potentiated analgesia produced by morphine and endogenous opiates and seemed to reverse tolerance. These results suggest that endogenous cholecystokinin systems oppose the action of opiates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Watkins, L R -- Kinscheck, I B -- Mayer, D J -- DA 00576/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1984 Apr 27;224(4647):395-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6546809" target="_blank"〉PubMed〈/a〉
Keywords:
*Analgesia
;
Animals
;
Brain/drug effects
;
Dose-Response Relationship, Drug
;
Drug Synergism
;
Drug Tolerance/drug effects
;
Endorphins/physiology
;
Enkephalin, Methionine/analogs & derivatives/pharmacology
;
Glutamine/*analogs & derivatives
;
Humans
;
Injections, Spinal
;
Morphine/*pharmacology
;
Proglumide/administration & dosage/*pharmacology
;
Rats
;
Spinal Cord/drug effects
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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