Publication Date:
1994-08-26
Description:
Estrogen and progesterone modulate gene expression in rodents by activation of intracellular receptors in the hypothalamus, which regulate neuronal networks that control female sexual behavior. However, the neurotransmitter dopamine has been shown to activate certain steroid receptors in a ligand-independent manner. A dopamine receptor stimulant and a D1 receptor agonist, but not a D2 receptor agonist, mimicked the effects of progesterone in facilitating sexual behavior in female rats. The facilitory effect of the neurotransmitter was blocked by progesterone receptor antagonists, a D1 receptor antagonist, or antisense oligonucleotides to the progesterone receptor. The results suggest that in rodents neurotransmitters may regulate in vivo gene expression and behavior by means of cross-talk with steroid receptors in the brain.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mani, S K -- Allen, J M -- Clark, J H -- Blaustein, J D -- O'Malley, B W -- MH-00885/MH/NIMH NIH HHS/ -- NS 19327/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1994 Aug 26;265(5176):1246-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7915049" target="_blank"〉PubMed〈/a〉
Keywords:
Adrenal Glands/drug effects
;
Animals
;
Base Sequence
;
Benzazepines/pharmacology
;
Dopamine/*physiology
;
Dopamine Agents/administration & dosage/pharmacology
;
Estradiol/analogs & derivatives/pharmacology
;
Female
;
Hypothalamus/drug effects/*physiology
;
Injections, Intraventricular
;
Male
;
Molecular Sequence Data
;
Oligonucleotides, Antisense/pharmacology
;
Posture
;
Progesterone/pharmacology/*physiology
;
Rats
;
Rats, Sprague-Dawley
;
Receptors, Progesterone/genetics/*physiology
;
Sexual Behavior, Animal/drug effects/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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