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  • Documentation and Information Science  (1)
  • Statistics and Probability; Astrodynamics  (1)
  • actin  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Molecular and cellular biochemistry 135 (1994), S. 1-9 
    ISSN: 1573-4919
    Keywords: calcium ; contraction ; artery ; smooth muscle ; actin ; myosin ; phosphorylation ; calmodulin ; myosin light chain kinase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract The fact that smooth muscle exists in almost every hollow organ and is involved in a large number of disease states has led to a vast increase in smooth muscle research, covering areas from testing response to antagonists and agonists to measuring the molecular force generated by a single actin filament. Yet, the exact mechanisms regulating contractile response of smooth muscle remain unsolved. Calcium has been a central player in mediating smooth muscle contraction through binding with calmodulin, although there is evidence showing that under special circumstances smooth muscle can contract without change in intracellular Ca2+. In addition to the major regulatory pathway of Ca2+-calmodulin-mysoin light chain kinase, there are other thin filament linked regulatory mechanisms in which Ca2+-calmodulin dependent phosphorylation of calponin and caldesmon may be involved. Ca2+ sensitivity of smooth muscle contraction may vary under different situations and this has recently been recognized as an important regulatory mechanism. Examples are protein kinase C (PKC) dependent phosphorylation of myosin light chain kinase which results in partial inhibition of contraction, and activation of myosin light chain phosphatase. There is new evidence howing that not only does Ca2+ regulate contraction by regulating the interaction of contractile proteins in smooth muscle, but also that shortening of smooth muscle itself reduces intracellular Ca2+ concentration, via a negative feedback.
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 2019-08-23
    Description: The NASA Conjunction Assessment Risk Analysis (CARA) program has been performing routine on-orbit satellite conjunction risk analysis for unmanned NASA spacecraft since 2005, and has developed a robust operations procedure and set of recommended best practices for operational conjunction assessment. However, a number of recent developments in Space Situational Awareness and commercial space operations conduct, such as the immanent deployment of much more sensitive space sensing systems and the launching of much larger satellite constellations, have begun to challenge these standard collision risk parameters and calculations. In response CARA has pursued a multi-year evaluation initiative to re-examine risk assessment algorithms and techniques, to develop needed improvements, and to assemble analysis-based operational requirements. This paper gives an overview of the principal parts of the Conjunction Assessment (CA) risk assessment process used at CARA, outlines the technical challenges that each part presents, surveys the possible solutions, and then indicates which particular solution is being recommended for NASA.
    Keywords: Documentation and Information Science
    Type: GSFC-E-DAA-TN71117-2 , AAS/AIAA Astrodynamics Specialist Conference; Aug 11, 2019 - Aug 15, 2019; Portland, ME; United States
    Format: application/pdf
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  • 3
    Publication Date: 2019-07-13
    Description: No abstract available
    Keywords: Statistics and Probability; Astrodynamics
    Type: GSFC-E-DAA-TN35046 , (AMOS) Advanced Maui Optical and Space Surveillance Technologies Conference; Sep 20, 2016 - Sep 23, 2016; Wailea, Maui, HI; United States
    Format: application/pdf
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