Publication Date:
2005-07-16
Description:
Neurofibrillary tangles (NFTs) are the most common intraneuronal inclusion in the brains of patients with neurodegenerative diseases and have been implicated in mediating neuronal death and cognitive deficits. Here, we found that mice expressing a repressible human tau variant developed progressive age-related NFTs, neuronal loss, and behavioral impairments. After the suppression of transgenic tau, memory function recovered, and neuron numbers stabilized, but to our surprise, NFTs continued to accumulate. Thus, NFTs are not sufficient to cause cognitive decline or neuronal death in this model of tauopathy.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1574647/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1574647/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Santacruz, K -- Lewis, J -- Spires, T -- Paulson, J -- Kotilinek, L -- Ingelsson, M -- Guimaraes, A -- DeTure, M -- Ramsden, M -- McGowan, E -- Forster, C -- Yue, M -- Orne, J -- Janus, C -- Mariash, A -- Kuskowski, M -- Hyman, B -- Hutton, M -- Ashe, K H -- P01 AG015453/AG/NIA NIH HHS/ -- P01-AG15453/AG/NIA NIH HHS/ -- R01 AG008487/AG/NIA NIH HHS/ -- R01 AG026249/AG/NIA NIH HHS/ -- R01 AG026252/AG/NIA NIH HHS/ -- R01 NS033249/NS/NINDS NIH HHS/ -- R01 NS046355/NS/NINDS NIH HHS/ -- R01-026252/PHS HHS/ -- R01-AG08487/AG/NIA NIH HHS/ -- R01-AG26249/AG/NIA NIH HHS/ -- R01-NS46355/NS/NINDS NIH HHS/ -- T31-AG00277/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2005 Jul 15;309(5733):476-81.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16020737" target="_blank"〉PubMed〈/a〉
Keywords:
Aging
;
Animals
;
Atrophy
;
Brain/*metabolism/pathology
;
Cognition
;
Disease Progression
;
Doxycycline/pharmacology
;
Hippocampus/metabolism/pathology
;
Humans
;
Maze Learning
;
*Memory
;
Mice
;
Mice, Transgenic
;
Neurodegenerative Diseases/metabolism/*pathology/*physiopathology
;
Neurofibrillary Tangles/metabolism/*pathology
;
Neuronal Plasticity
;
Neurons/metabolism/pathology
;
Organ Size
;
Phosphorylation
;
RNA, Messenger/genetics/metabolism
;
Solubility
;
tau Proteins/chemistry/genetics/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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