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  • 1
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    Comment on "Tumor growth need not be driven by rare cancer stem cells" (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-12-15
    Description: Kelly et al. (Brevia, 20 July 2007, p. 337) questioned xenotransplant experiments supporting the cancer stem cell (CSC) hypothesis because they found a high frequency of leukemia-initiating cells (L-IC) in some transgenic mouse models. However, the CSC hypothesis depends on prospective purification of cells with tumor-initiating capacity, irrespective of frequency. Moreover, we found similar L-IC frequencies in genetically comparable leukemias using syngeneic or xenogeneic models.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kennedy, James A -- Barabe, Frederic -- Poeppl, Armando G -- Wang, Jean C Y -- Dick, John E -- New York, N.Y. -- Science. 2007 Dec 14;318(5857):1722; author reply 1722.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Cell and Molecular Biology, University Health Network, Toronto, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18079385" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone Marrow Cells/pathology ; Bone Marrow Transplantation ; Cell Separation ; Disease Models, Animal ; Humans ; Leukemia/*pathology/physiopathology ; Leukemia, Myeloid, Acute/pathology/physiopathology ; Mice ; Mice, Transgenic ; Neoplasm Transplantation ; Neoplastic Stem Cells/pathology/*physiology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology/physiopathology ; Transplantation, Heterologous
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Engraftment of immune-deficient mice with human hematopoietic stem cells (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1988-12-23
    Description: A system in which immune-deficient mice are repopulated with cells from the human myeloid lineage, and that provides an in vivo stem cell assay for human hematopoietic cells is described. Generation of the chimeric human/immune-deficient (HID) mice was dependent on the use of immune-deficient bg/nu/xid mice. Infusion of these mice with human bone marrow gave rise to increases in human macrophage progenitors during more than 5 weeks of in vivo growth, indicating the seeding, proliferation, and differentiation of human stem cells. The human identity of the progenitors was confirmed by sequence analysis and their dependence on human growth factors. The creation of HID mice lays the foundation for establishing animal models for a wide variety of human hemopathies, from leukemia to infectious disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kamel-Reid, S -- Dick, J E -- New York, N.Y. -- Science. 1988 Dec 23;242(4886):1706-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, Hospital for Sick Children, Toronto, Ontario.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2904703" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone Marrow Transplantation ; Cell Differentiation ; Cell Division ; Colony-Forming Units Assay ; Colony-Stimulating Factors/pharmacology ; Disease Models, Animal ; Granulocyte-Macrophage Colony-Stimulating Factor ; Growth Substances/pharmacology ; Hematologic Diseases ; *Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells/pathology ; Humans ; *Immunologic Deficiency Syndromes/immunology/pathology ; Interleukin-3/pharmacology ; Killer Cells, Natural/immunology ; Macrophages/pathology ; Mice ; Mice, Inbred CBA ; Mice, Mutant Strains ; Mice, Nude ; Transplantation, Heterologous
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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