ISSN:
1434-193X
Keywords:
Nucleosides
;
Glycosylations
;
Lewis acids
;
Disaccharide nucleosides
;
Trisaccharide nucleosides
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The unexpected formation of trisaccharide nucleosides during synthesis of disaccharide nucleosides with a purine base moiety has been observed. The occurrence of this side reaction can be explained in terms of the instability of the protected purine nucleosides in the presence of Lewis acids. The formation of these by-products can be avoided by using the 2,3-O-isopropylidene group instead of acyl groups for the blocking of the secondary hydroxyl groups of the nucleoside.
Type of Medium:
Electronic Resource
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