ISSN:
0935-6304
Keywords:
Gas chromatography, GC
;
Fused silica and glass capillary columns
;
Enantiomer and diastereomer resolution
;
Chirasil-Val
;
Dipeptides
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Several dipeptides have been separated into stereoisomers (enantiomers, diastereoisomers, sequential isomers) by GC on the chiral stationary phase Chirasil-Val. Sufficiently volatile N-TFA-dipeptide methyl esters have been formed by derivatization at ambient temperature, thus avoiding racemization (or epimerization, respectively), and peptide cleavage. This novel approach has proven particularly useful for the determination of stereoisomeric composition of dipeptides in biological fluids.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jhrc.1240100518
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