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Histological study of ibotenic acid-induced modifications of rat retina and their attenuation by diazepam (1984)

Perez-Rico, C. ; Gomez-Ramos, P.

Springer

Cell & tissue research 238 (1984), S. 81-85

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ISSN: 1432-0878

Keywords: Retina ; Ibotenic acid ; Toxicity ; Rat

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary After 2 h intraocular injections of 19 and 190 nmoles ibotenic acid in the rat retina produced an intensive vacuolization of the inner plexiform layer and cellular alterations, in the inner nuclear layer and ganglion cell layer. These alterations consisted of either cytoplasmic swelling accompanied by clumping of the nuclear chromatin or darkening of the cytoplasm along with nuclear condensation. A week later the retinas were thinner than the controls due to the disappearance of the affected cells. Pre-treatment with diazepam prevents the morphological alterations induced by 19 nmoles ibotenic acid; mainly the swelling, which was completely prevented, while the darkening was reduced drastically, although some vacuolization of the inner plexiform layer is still present.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00215147

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Capillary gas chromatography of amino acids as their tert-butyldimethylsilyl derivatives in the analysis of serum amino acids in metabolic diseases (1988)

Chaves Das Neves, H. J. ; Vasconcelos, A. M. P. ; Tavares, J. Rueff ; [et al.]

Weinheim : Wiley-Blackwell

Journal of High Resolution Chromatography 11 (1988), S. 12-16

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ISSN: 0935-6304

Keywords: Gas chromatography, GC ; Capillary column ; Amino acids ; Derivatization ; Serum ; Chemistry ; Analytical Chemistry and Spectroscopy

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: Reaction of amino acids with N-methyl-N-(tert-butyldimethylsilyl)trifluoroaceamide (MTbSTFA) in acetonitrile affords good yields of amino acid derivatives with excellent gas chromatographic and mass spectrometric properties. The single-step derivatization procedure is highly reproducible. The TBDMS amino acids are stable at room temperature for at least three days. Only a single peak is observed for each amino acid. The procedure allows simultaneous analysis of asparagine and glutamine together with other serum amino acids. Separation is achieved on a borosilicate glass capillary coated with OV-1. The mass spectra of the TBDMS amino acids possess characteristic diagnostic ions. These properties were used in the sensitive detection by GC-MS and SIM-GC-MS of GABA and pipecolic acid in the serum of a newborn suspected of a Zellweger-type syndrome, which could not be detected by other methods.

Additional Material: 6 Ill.