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  • 1
    Electronic Resource
    Electronic Resource
    Recombinational repair of hydrogen peroxide-induced damages in DNA of phage T4
    Amsterdam : Elsevier
    Mutation Research DNA Repair Reports 184 (1987), S. 87-98 
    Details
    ISSN: 0167-8817
    Keywords: DNA damage ; Hydrogen peroxide-induced damage ; Phage T4 ; Recombinational repair
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-8817(87)90064-2
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  • 2
    Electronic Resource
    Electronic Resource
    A potent converting enzyme inhibitor CGS 13928C. Drug profile in normal volunteers (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 419-424 
    Details
    ISSN: 1432-1041
    Keywords: converting enzyme inhibitor ; blood pressure decrease ; exogenous angiotensin ; plasma angiotensin I and II ; plasma renin ; aldosterone ; healthy male volunteers ; CGS 13928C
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The converting enzyme inhibitor CGS 13928C was evaluated in 15 healthy male volunteers. First the efficacy of a single oral dose of 0.5, 1, 2 or 5 mg in antagonizing the pressor response to exogenous angiotensin I was tested with continuous monitoring of the blood pressure and heart rate by an intraarterial catheter. CGS 13928C 1, 2 and 5 mg consistently reduced the response to angiotensin within 2 to 3 h and for a period exceeding the 4 h of monitoring. The 2 mg dose was hardly more effective than 1 mg and 5 mg did not further enhance the blockade. Subsequently, plasma renin and converting enzyme activity, angiotensin I, angiotensin II and aldosterone were measured serially before and up to 72 h following oral administration of either 1 mg (n=7) or 2 mg (n=8) CGS 13928C. As expected, plasma renin activity and angiotensin I rose, while plasma converting enzyme activity, angiotensin II and aldosterone fell following both doses of the drug. No side-effects occurred. In normal volunteers CGS 13928C is an effective and extremely potent, orally active converting enzyme inhibitor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542134
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  • 3
    Electronic Resource
    Electronic Resource
    Inhibition by singlet oxygen quenchers of oxidative damage to DNA produced in cultured cells by exposure to a quinolone antibiotic and ultraviolet A irradiation (1998)
    Springer
    Cell biology and toxicology 14 (1998), S. 237-242 
    Details
    ISSN: 1573-6822
    Keywords: singlet oxygen ; 7,8-dihydro-8-oxo-2′-deoxyguanosine ; DNA damage ; 8-oxo-dG ; sodium azide ; 2,2,6,6-tetramethyl-4-piperadone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The photogenotoxicity mechanism of quinolone antibiotics was investigated by measuring oxidative DNA damage in lomefloxacin- and UVA-exposed cultured liver-derived cells. The combination of lomefloxacin and UVA irradiation produced a dose-dependent increase in 7,8-dihydro-8-oxo-2′-deoxyguanosine (8-oxo-dG) in cell DNA. This DNA damage was substantially inhibited by co-incubation with sodium azide (NaN3) or 2,2,6,6-tetramethyl-4-piperadone (TMP), chemicals that specifically quench singlet oxygen. No significant reduction of 8-oxo-dG formation was produced by N-t-butyl-α-phenylnitrone (TBP) or α-tocopherol, which primarily scavenge hydroxyl radicals. We conclude that the photodynamic generation of 8-oxo-dG by quinolones is mediated, at least in part, by singlet oxgen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007474912498
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