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  • 1
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    HIV-1 reverse transcriptase is a target for cytotoxic T lymphocytes in infected individuals (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1988-04-01
    Description: Characterization of the host immune response to human immunodeficiency virus type 1 (HIV-1) is critical to the rational design of an effective AIDS vaccine. In this study, cytotoxic T lymphocytes (CTL) specific for HIV-1 reverse transcriptase (RNA-dependent DNA polymerase) were found in blood samples from HIV-1-infected individuals. CTL targets were prepared by immortalizing B cells from ten seropositive and six seronegative individuals, and then infecting these cells with recombinant vaccinia viruses containing HIV-1 genes. CTL directed against autologous B lymphoblasts expressing HIV-1 reverse transcriptase were detected in fresh blood samples from eight HIV-1 seropositive subjects, but in no seronegative controls. The effector cells were identified as major histocompatibility complex-restricted CD3+CD8+ lymphocytes. Because the HIV-1 pol gene is highly conserved among different isolates and generates both humoral and cellular immune responses, it bears consideration for inclusion in a candidate AIDS vaccine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walker, B D -- Flexner, C -- Paradis, T J -- Fuller, T C -- Hirsch, M S -- Schooley, R T -- Moss, B -- CA37461/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1988 Apr 1;240(4848):64-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Infectious Disease Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2451288" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*immunology ; Antigens, Viral/immunology ; B-Lymphocytes/immunology ; DNA, Recombinant ; Genes, Viral ; HIV/*enzymology/genetics ; HIV Seropositivity ; HLA Antigens/immunology ; Humans ; RNA-Directed DNA Polymerase/*immunology ; T-Lymphocytes, Cytotoxic/*immunology ; Vaccinia virus/genetics/immunology ; Viral Vaccines/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Vaccinia virus recombinants: expression of VSV genes and protective immunization of mice and cattle (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-01-25
    Description: Vesicular stomatitis virus (VSV) causes a contagious disease of horses, cattle, and pigs. When DNA copies of messenger RNA's for the G or N proteins of VSV were linked to a vaccinia virus promoter and inserted into the vaccinia genome, the recombinants retained infectivity and synthesized VSV polypeptides. After intradermal vaccination with live recombinant virus expressing the G protein, mice produced VSV-neutralizing antibodies and were protected against lethal encephalitis upon intravenous challenge with VSV. In cattle, the degree of protection against intradermalingually injected VSV was correlated with the level of neutralizing antibody produced following vaccination.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mackett, M -- Yilma, T -- Rose, J K -- Moss, B -- New York, N.Y. -- Science. 1985 Jan 25;227(4685):433-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2981435" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Viral/analysis ; Cattle ; Cattle Diseases/prevention & control ; *Cloning, Molecular ; DNA, Recombinant ; Genes, Viral ; *Membrane Glycoproteins ; Mice ; Operon ; Stomatitis/prevention & control/veterinary ; Vaccination/veterinary ; Vaccinia virus/*genetics ; Vesicular stomatitis Indiana virus/genetics/*immunology ; *Viral Envelope Proteins ; Viral Proteins/biosynthesis/*immunology ; Viral Vaccines/*immunology ; Virus Diseases/prevention & control/*veterinary
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    T-lymphocyte priming and protection against Friend leukemia by vaccinia-retrovirus env gene recombinant (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-11-07
    Description: The current prevalence of the acquired immune deficiency syndrome in humans has provoked renewed interest in methods of protective immunization against retrovirus-induced diseases. In this study, a vaccinia-retrovirus recombinant vector was constructed to study mechanisms of immune protection against Friend virus leukemia in mice. The envelope (env) gene from Friend murine leukemia virus (F-MuLV) was inserted into the genome of a vaccinia virus expression vector. Infected cells synthesized gp85, the glycosylated primary product of the env gene. Processing to gp70 and p15E, and cell surface localization, were similar to that occurring in cells infected with F-MuLV. Mice inoculated with live recombinant vaccinia virus had an envelope-specific T-cell proliferative response and, after challenge with Friend virus complex, developed neutralizing antibody and cytotoxic T cells (CTL) and were protected against leukemia. In contrast, unimmunized and control groups developed a delayed neutralizing antibody response, but no detectable CTL, and succumbed to leukemia. Genes of the major histocompatibility complex influenced protection induced by the vaccinia recombinant but not that induced by attenuated N-tropic Friend virus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Earl, P L -- Moss, B -- Morrison, R P -- Wehrly, K -- Nishio, J -- Chesebro, B -- New York, N.Y. -- Science. 1986 Nov 7;234(4777):728-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3490689" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Viral/immunology ; Antigens/*immunology ; DNA, Recombinant ; Female ; Friend murine leukemia virus/genetics/immunology ; *Genes, Viral ; Leukemia, Erythroblastic, Acute/prevention & control ; Leukemia, Experimental/*prevention & control ; Lymphocyte Activation ; Male ; Mice ; Mice, Inbred Strains ; Sex Factors ; Spleen/microbiology ; T-Lymphocytes/*immunology ; T-Lymphocytes, Cytotoxic/immunology ; Vaccines, Synthetic/*immunology ; Vaccinia virus/genetics/immunology ; Viral Envelope Proteins/genetics/*immunology ; Viral Vaccines/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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