ISSN:
1434-193X
Keywords:
Morphine alkaloids
;
6,14-Ethenomorphinans
;
Chromium(II) complex reagents
;
Organochromium(III) complex intermediates
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
-A synthetic method for the selective transformations of a selected morphine alkaloid in neutral aqueous medium is introduced. Full diastereoselectivity was achieved by the transformation of nepenthone (1) with [Cr(ida)(H2O)3] into 2a (20R) showing a complementary method as compared to the reactions with classical reagents to result in 2b (20S). A new unexpected morphine derivative 3 was prepared by a ligand-induced modification of the reaction which involves an unprecedented rearrangement.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
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