ISSN:
1432-072X
Keywords:
Cyanobacteria
;
Secondary metabolite
;
Antifungal
;
Cytotoxin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract Tolytoxin, a macrocyclic lactone, is a potent antifungal antibiotic, exhibiting MICs in the range of 0.25 to 8 nanomolar. Tolytoxin also inhibits the growth of a variety of mammalian cells at similar doses, without specific inhibition of macromolecular synthesis. The effects in mammalian cells are primarily cytostatic, with cell death being time-and dose-dependent. Tolytoxin is highly toxic to mice, exhibiting an LD50 (ip) of 1.5 mg/kg. No antibacterial, antiviral, or hemolytic activities were observed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00249096
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