Publication Date:
2010-04-03
Description:
Cytomegalovirus (CMV) can superinfect persistently infected hosts despite CMV-specific humoral and cellular immunity; however, how it does so remains undefined. We have demonstrated that superinfection of rhesus CMV-infected rhesus macaques (RM) requires evasion of CD8+ T cell immunity by virally encoded inhibitors of major histocompatibility complex class I (MHC-I) antigen presentation, particularly the homologs of human CMV US2, 3, 6, and 11. In contrast, MHC-I interference was dispensable for primary infection of RM, or for the establishment of a persistent secondary infection in CMV-infected RM transiently depleted of CD8+ lymphocytes. These findings demonstrate that US2-11 glycoproteins promote evasion of CD8+ T cells in vivo, thus supporting viral replication and dissemination during superinfection, a process that complicates the development of preventive CMV vaccines but that can be exploited for CMV-based vector development.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883175/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883175/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hansen, Scott G -- Powers, Colin J -- Richards, Rebecca -- Ventura, Abigail B -- Ford, Julia C -- Siess, Don -- Axthelm, Michael K -- Nelson, Jay A -- Jarvis, Michael A -- Picker, Louis J -- Fruh, Klaus -- AI040101/AI/NIAID NIH HHS/ -- P51 RR000163/RR/NCRR NIH HHS/ -- P51 RR000163-460222/RR/NCRR NIH HHS/ -- P51 RR000163-486829/RR/NCRR NIH HHS/ -- P51 RR000163-496081/RR/NCRR NIH HHS/ -- P51 RR000163-508648/RR/NCRR NIH HHS/ -- R01 AI021640/AI/NIAID NIH HHS/ -- R01 AI021640-26/AI/NIAID NIH HHS/ -- R01 AI059457/AI/NIAID NIH HHS/ -- R01 AI059457-01A2/AI/NIAID NIH HHS/ -- R01 AI059457-02/AI/NIAID NIH HHS/ -- R01 AI059457-03/AI/NIAID NIH HHS/ -- R01 AI059457-04/AI/NIAID NIH HHS/ -- R01 AI059457-05/AI/NIAID NIH HHS/ -- R01 AI060392/AI/NIAID NIH HHS/ -- RR00163/RR/NCRR NIH HHS/ -- RR016001/RR/NCRR NIH HHS/ -- RR016025/RR/NCRR NIH HHS/ -- RR18107/RR/NCRR NIH HHS/ -- T32 AI007472/AI/NIAID NIH HHS/ -- T32 HL007781/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2010 Apr 2;328(5974):102-6. doi: 10.1126/science.1185350.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Vaccine and Gene Therapy Institute, Oregon Health and Science University, 505 Northwest 185th Avenue, Beaverton, OR 97006, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20360110" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigen Presentation
;
CD4-Positive T-Lymphocytes/immunology
;
CD8-Positive T-Lymphocytes/*immunology
;
Cytomegalovirus/genetics/immunology/*physiology
;
Cytomegalovirus Infections/*immunology/*virology
;
Cytomegalovirus Vaccines/immunology
;
Disease Models, Animal
;
Gene Products, gag/immunology
;
Genes, Viral
;
Histocompatibility Antigens Class I/immunology
;
*Immune Evasion
;
Immunologic Factors/genetics/*physiology
;
Macaca mulatta
;
Male
;
Simian Immunodeficiency Virus/genetics/immunology
;
Superinfection
;
Viral Proteins/genetics/*physiology
;
Virus Replication
;
Virus Shedding
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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