Publikationsdatum:
2008-09-06
Beschreibung:
Recovery from Friend virus 3 (Rfv3) is a single autosomal gene encoding a resistance trait that influences retroviral neutralizing antibody responses and viremia. Despite extensive research for 30 years, the molecular identity of Rfv3 has remained elusive. Here, we demonstrate that Rfv3 is encoded by Apobec3. Apobec3 maps to the same chromosome region as Rfv3 and has broad inhibitory activity against retroviruses, including HIV. Not only did genetic inactivation of Apobec3 convert Rfv3-resistant mice to a susceptible phenotype, but Apobec3 was also found to be naturally disabled by aberrant messenger RNA splicing in Rfv3-susceptible strains. The link between Apobec3 and neutralizing antibody responses highlights an Apobec3-dependent mechanism of host protection that might extend to HIV and other human retroviral infections.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701658/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701658/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Santiago, Mario L -- Montano, Mauricio -- Benitez, Robert -- Messer, Ronald J -- Yonemoto, Wes -- Chesebro, Bruce -- Hasenkrug, Kim J -- Greene, Warner C -- R01 AI065329/AI/NIAID NIH HHS/ -- R01 AI065329-04/AI/NIAID NIH HHS/ -- Intramural NIH HHS/ -- New York, N.Y. -- Science. 2008 Sep 5;321(5894):1343-6. doi: 10.1126/science.1161121.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18772436" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Animals
;
Antibodies, Viral/*biosynthesis/blood/immunology
;
Chromosome Mapping
;
Cloning, Molecular
;
Cytidine Deaminase/*genetics/metabolism
;
Friend murine leukemia virus/*immunology/physiology
;
Immunity, Innate
;
Mice
;
Mice, Inbred BALB C
;
Mice, Inbred C57BL
;
Molecular Sequence Data
;
Neutralization Tests
;
Retroviridae Infections/genetics/*immunology/virology
;
Tumor Virus Infections/genetics/*immunology/virology
;
Viremia
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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