ALBERT — All Library Books, journals and Electronic Records Telegrafenberg

Hits per page

hits 1 - 2 | 2 hits

Sorting

Electronic Resource

Effects of low-dose prednisolone on cyclosporine pharmacokinetics in liver transplant recipients: radioimmunoassay with specific and non-specific monoclonal antibodies (1990)

Arnold, J. C. ; O'Grady, J. G. ; Tredger, J. M. ; [et al.]

Springer

European journal of clinical pharmacology 39 (1990), S. 257-260

add to mindlist on the mindlist

Details

ISSN: 1432-1041

Keywords: Cyclosporine pharmacokinetics ; Prednisolone ; Liver transplantation

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary The following study of cyclosporine pharmacokinetics was performed to investigate the effects of withdrawal of low-dose maintenance prednisolone (0.3–0.6 mg/kg body weight) from the routine immunosuppressive regimen given to 10 liver transplant recipients with stable liver function tests. After oral administration of cyclosporine (6.4–10.3 mg/kg) whole blood concentrations were measured by radioimmunoassay (RIA) with both a specific monoclonal antibody detecting parent drug and a non-specific antibody additionally detecting a cross-section of metabolites. Withdrawal of prednisolone produced no significant change in the mean time and concentration of maximum blood cyclosporine (3.3 h and 1160 μg/l, respectively), the initial and terminal elimination half-life (3.5 h and 18.4 h, respectively) and the area under the blood concentration versus time curve (AUC) measured with either the specific or non-specific monoclonal antibody. Measurements with these two antibodies indicated that the terminal elimination of cyclosporine metabolites was more rapid than for the parent drug (half-life: 14.5 vs 18.4, respectively).

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00315106

Permalink

	Location	Call Number	Expected	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

Electronic Resource

The influence of physical aging on the creep rupture behavior of polystyrene (1993)

Arnold, J. C.

Bognor Regis [u.a.] : Wiley-Blackwell

Journal of Polymer Science Part B: Polymer Physics 31 (1993), S. 1451-1458

add to mindlist on the mindlist

Details

ISSN: 0887-6266

Keywords: polystyrene ; postannealing aging time ; brittle fracture behavior ; creep rupture ; Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Physics

Notes: The effects of postannealing aging time on the brittle fracture behavior of polystyrene were studied. A combination of mechanical properties, including creep and creep rupture under constant load and the behavior under constant extension rate deformation were examined for polystyrene samples of different prior aging times (from 1h to 2 months). The specimens and fracture surfaces were examined by optical microscopy and SEM to observe any change in the fracture behavior. It was found that longer aging times caused not only a change in the time-dependent modulus of the material but also a significant decrease in the creep rupture life and a decrease in strain to failure. It was found that the reasons for this are that although aging delays craze formation, craze breakdown and ultimate failure are accelerated by aging. The importance of these findings are discussed, particularly in relation to failure criteria involving the use of critical strains. © 1993 John Wiley & Sons, Inc.

Additional Material: 9 Ill.