ISSN:
1573-3904
Keywords:
Aggregometry
;
Cyclic peptide
;
Diazaethyleneglycol derivative
;
HEL cell adhesion
;
RGD peptide
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract This paper investigates the effect of the incorporation of adiazaethylene glycol derivative (Deg, 2) into a cyclic peptide containingthe tripeptide sequence Arg-Gly-Asp (RGD). This motif is a common structuralelement of many integrin ligands. The synthesis of cyclo-(Arg-Gly-Asp-Deg)(7) has been accomplished in solution using standard peptide chemistry. Theintent was to improve the bioavailability of this new RGD cyclic peptide,which is shown to interact with αIIbΒ3β3or α5 β1 receptors. A preliminary stepfor the conformational study of peptide 7 was done in DMSO-d6using nuclear magnetic resonance spectroscopy techniques.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008844117525
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