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  • N-Acylation  (2)
  • Cyclic dipeptides  (1)
  • N-ProtectedN-acyl amino acids  (1)
  • N-protected carboxyanhydrides (UNCAs)  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    International journal of peptide research and therapeutics 4 (1997), S. 241-244 
    ISSN: 1573-3904
    Keywords: Urethane N-protected carboxyanhydrides (UNCAs) ; N-ProtectedN-acyl amino acids ; N-Acylation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The reactivity of Grignard reagents with UNCAs (Urethane N-protected Carboxyanhydrides of Amino acids) is described. We observed that, depending on the method of addition of the organometallic compounds, the reaction proceeded differently: (i) when the UNCA was added to the Grignard reagent, we obtained a mixture of five different products which were all identified; and (ii) when the organometallic reagent was added to the UNCA, we also obtained a mixture of the same products but in different proportions, with the major component corresponding to the urethane N-protectedN-acyl amino acid derivative.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1434-193X
    Keywords: Amino acids ; coupling ; N-Substituted amide ; Cyclizations ; Cyclic dipeptides ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---A short synthesis of new, functionalized seven-membered ring cyclic dipeptides is described. After the coupling of N-protected β-amino acids to N-substituted α-amino tert-butyl esters, the protective groups of the terminal functions were removed and the cyclization took place diastereoselectively in the presence of the coupling agent BOP. Amide substitution was found to be effective in promoting the cyclization of linear dipeptides.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    International journal of peptide research and therapeutics 4 (1997), S. 241-244 
    ISSN: 1573-3904
    Keywords: Urethane ; N-protected carboxyanhydrides (UNCAs) ; N-protected N-acyl amino acids ; N-Acylation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The reactivity of Grignard reagents with UNCAs (UrethaneN-protected Carboxyanhydrides of Amino acids)is described. We observed that, depending on the method ofaddition of the organometallic compounds, the reactionproceeded differently:(i) when the UNCA was added to the Grignard reagent, weobtained a mixture of five different products whichwere all identified; and (ii) when the organometallic reagent was added to theUNCA, we also obtained a mixture of the same productsbut in different proportions, with the major componentcorresponding to the urethane N-protected N-acyl aminoacid derivative.
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
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