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  • 1
    Publication Date: 2016-02-20
    Description: Somatic mosaicism refers to the existence of somatic mutations in a fraction of somatic cells in a single biological sample. Its importance has mainly been discussed in theory although experimental work has started to emerge linking somatic mosaicism to disease diagnosis. Through novel statistical modeling of paired-end DNA-sequencing data using blood-derived DNA from healthy donors as well as DNA from tumor samples, we present an ultra-fast computational pipeline, LocHap that searches for multiple single nucleotide variants (SNVs) that are scaffolded by the same reads. We refer to scaffolded SNVs as local haplotypes (LH). When an LH exhibits more than two genotypes, we call it a local haplotype variant (LHV). The presence of LHVs is considered evidence of somatic mosaicism because a genetically homogeneous cell population will not harbor LHVs. Applying LocHap to whole-genome and whole-exome sequence data in DNA from normal blood and tumor samples, we find wide-spread LHVs across the genome. Importantly, we find more LHVs in tumor samples than in normal samples, and more in older adults than in younger ones. We confirm the existence of LHVs and somatic mosaicism by validation studies in normal blood samples. LocHap is publicly available at http://www.compgenome.org/lochap .
    Keywords: Polymorphism/mutation detection
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
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  • 2
    Publication Date: 2016-02-27
    Description: Author(s): Shan Dong, Anmin Zhang, Kai Liu, Jianting Ji, Y. G. Ye, X. G. Luo, X. H. Chen, Xiaoli Ma, Yinghao Jie, Changfeng Chen, Xiaoqun Wang, and Qingming Zhang The recent renaissance of black phosphorus (BP) as a two-dimensional (2D) layered material has generated tremendous interest, but its unique structural characters underlying many of its outstanding properties still need elucidation. Here we report Raman measurements that reveal an ultralow-frequency… [Phys. Rev. Lett. 116, 087401] Published Fri Feb 26, 2016
    Keywords: Condensed Matter: Electronic Properties, etc.
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
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  • 3
    Publication Date: 2019-07-13
    Description: No abstract available
    Keywords: Meteorology and Climatology
    Type: GSFC.CPR.00167.2012 , European Geosciences Union General Assembly 2012; Apr 22, 2012 - Apr 27, 2012; Vienna; Austria
    Format: application/pdf
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  • 4
    Publication Date: 2019-07-13
    Description: NASA has a long standing commitment to the improvement of its mission datasets. Indeed, data reprocessing is always built into the plans, schedule and budget for the mission data processing system. However, in addition to these ongoing mission reprocessing, NASA also supports a final reprocessing of all the data for a mission upon its completion (known as Phase F). TRMM Phase F started with the end of the TRMM mission in June of 2015. This last reprocessing has two overall goals: improvement of the TRMM mission data products; incorporation of the 17+ years of TRMM data into the ongoing NASA/JAXA GPM data processing. The first goal guarantees that the latest algorithms used for precipitation retrievals will also be used in reprocessing the TRMM data. The second goal ensures that as GPM algorithms are improved, the entire TRMM data will always be reprocessed with each GPM reprocessing. In essence TRMM becomes another of the GPM constellation satellites. This paper will concentrate on presenting the improvements to TMI level 1 data including calibration, geolocation, and emissive antenna corrections. It will describe the format changes that will occur how the TMI level 1C product will be intercalibrated using GMI as the reference calibration. It will also provide an overview of changes in the precipitation radar products as well as the combined TMIPR product.
    Keywords: Meteorology and Climatology
    Type: GSFC-E-DAA-TN42161 , International Precipitation Working Group (IPWG) meeting; Oct 03, 2016 - Oct 07, 2016; Bologna; Italy|International Precipitation Working Group (IPWG) Joint Workshop; Oct 03, 2016 - Oct 07, 2016; Bologna; Italy
    Format: application/pdf
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