Publication Date:
2015-11-20
Description:
When used in combination with raster scanning, small-angle X-ray scattering (SAXS) has proven to be a valuable imaging technique of the nanoscale, for example of bone, teeth and brain matter. Although two-dimensional projection imaging has been used to characterize various materials successfully, its three-dimensional extension, SAXS computed tomography, poses substantial challenges, which have yet to be overcome. Previous work using SAXS computed tomography was unable to preserve oriented SAXS signals during reconstruction. Here we present a solution to this problem and obtain a complete SAXS computed tomography, which preserves oriented scattering information. By introducing virtual tomography axes, we take advantage of the two-dimensional SAXS information recorded on an area detector and use it to reconstruct the full three-dimensional scattering distribution in reciprocal space for each voxel of the three-dimensional object in real space. The presented method could be of interest for a combined six-dimensional real and reciprocal space characterization of mesoscopic materials with hierarchically structured features with length scales ranging from a few nanometres to a few millimetres--for example, biomaterials such as bone or teeth, or functional materials such as fuel-cell or battery components.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schaff, Florian -- Bech, Martin -- Zaslansky, Paul -- Jud, Christoph -- Liebi, Marianne -- Guizar-Sicairos, Manuel -- Pfeiffer, Franz -- England -- Nature. 2015 Nov 19;527(7578):353-6. doi: 10.1038/nature16060.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Lehrstuhl fur Biomedizinische Physik, Physik-Department &Institut fur Medizintechnik, Technische Universitat Munchen, 85748 Garching, Germany. ; Department of Medical Radiation Physics, Clinical Sciences, Lund, Lund University, 22185 Lund, Sweden. ; Julius Wolff Institute, Charite - Universitatsmedizin Berlin, 13353 Berlin, Germany. ; Paul Scherrer Institut, 5232 Villigen PSI, Switzerland. ; Institut fur diagnostische und interventionelle Radiologie, Klinikum rechts der Isar, Technische Universitat Munchen, 81675 Munchen, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26581292" target="_blank"〉PubMed〈/a〉
Keywords:
Collagen/ultrastructure
;
Humans
;
Imaging, Three-Dimensional/methods
;
Nanostructures/ultrastructure
;
*Scattering, Small Angle
;
Tomography/*methods
;
Tooth/ultrastructure
;
*X-Ray Diffraction
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
