Publication Date:
1979-04-13
Description:
Cis and trans dichlorodiaminoplatinum (II) compounds bind to DNA and form DNA cross-links, which are usually considered to be irreversible. Thiourea can reverse these cross-links without any apparent breakdown of the DNA. In addition, cis- and trans-Pt (II) treatment of lambda decreases its transfectivity. After suitable incubation with thiourea, full transfectivity of Pt(II)-treated lambda DNA can be restored.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Filipski, J -- Kohn, K W -- Prather, R -- Bonner, W M -- New York, N.Y. -- Science. 1979 Apr 13;204(4389):181-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/571145" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cell Line
;
Coliphages
;
DNA/*metabolism
;
DNA, Neoplasm/metabolism
;
DNA, Viral/metabolism
;
Leukemia L1210
;
Organoplatinum Compounds/*antagonists & inhibitors
;
Structure-Activity Relationship
;
Thiourea/*pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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