ISSN:
1434-193X
Keywords:
Glycosides
;
Clusters
;
Noncovalent interactions
;
Ligands
;
Receptors
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
A series of p-substituted aryl α-D-mannosides was synthesized and tested with regard to their inhibitory capacity in the hemagglutination of guinea pig erythrocytes by type 1 fimbriated Escherichia coli. Synthesis of the bivalent, phenyl-linked mannoside cluster 10 was complicated by orthoester formation during the glycosylation reaction. Surprisingly, the inhibitory potency of 10 was lower than that of p-nitrophenyl α-D-mannoside (1) and this is an important finding for the further design of clustered ligands.
Type of Medium:
Electronic Resource
Permalink