Publication Date:
2008-01-12
Description:
Natural selection is expected to eliminate genetic incompatibilities from interbreeding populations. We have discovered a globally distributed incompatibility in the primarily selfing species Caenorhabditis elegans that has been maintained despite its negative consequences for fitness. Embryos homozygous for a naturally occurring deletion of the zygotically acting gene zeel-1 arrest if their sperm parent carries an incompatible allele of a second, paternal-effect locus, peel-1. The two interacting loci are tightly linked, with incompatible alleles occurring in linkage disequilibrium in two common haplotypes. These haplotypes exhibit elevated sequence divergence, and population genetic analyses of this region indicate that natural selection is preserving both haplotypes in the population. Our data suggest that long-term maintenance of a balanced polymorphism has permitted the incompatibility to persist despite gene flow across the rest of the genome.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2421010/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2421010/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seidel, Hannah S -- Rockman, Matthew V -- Kruglyak, Leonid -- GM071508/GM/NIGMS NIH HHS/ -- R01 HG004321/HG/NHGRI NIH HHS/ -- R01 HG004321-01/HG/NHGRI NIH HHS/ -- R37 MH059520/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2008 Feb 1;319(5863):589-94. doi: 10.1126/science.1151107. Epub 2008 Jan 10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Lewis-Sigler Institute for Integrative Genomics and Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA. hseidel@princeton.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18187622" target="_blank"〉PubMed〈/a〉
Keywords:
Alleles
;
Animals
;
Animals, Genetically Modified
;
Caenorhabditis elegans/embryology/*genetics
;
Cloning, Molecular
;
Crosses, Genetic
;
Disorders of Sex Development
;
Embryo, Nonmammalian/physiology
;
Embryonic Development
;
Gene Flow
;
Genes, Helminth
;
Genetic Linkage
;
Genome, Helminth
;
Haplotypes
;
Linkage Disequilibrium
;
Male
;
Molecular Sequence Data
;
Penetrance
;
Polymorphism, Single Nucleotide
;
*Selection, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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