Publication Date:
1981-04-17
Description:
A clone of L1210 mouse leukemia cells selected for resistance to both the antiviral and anticellular properties of mouse interferon were essentially devoid of fatty acid cyclooxygenase activity. Experiments in which broken cell preparations were mixed or the two cell types were cultivated together failed to indicate the presence of a diffusible enzyme inhibitor. Fatty acid lipoxygenase activity of similar magnitude was detectable in both cell types. A selective impairment of fatty acid cyclooxygenase in interferon-resistant cells is consistent with recently described data suggesting that this enzyme may play a crucial role in mediating the antiviral and anticellular effects of interferon.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chandrabose, K A -- Cuatrecasas, P -- Pottathil, R -- Lang, D J -- New York, N.Y. -- Science. 1981 Apr 17;212(4492):329-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6163214" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Arachidonic Acids/metabolism
;
Cells, Cultured
;
Clone Cells/drug effects/enzymology
;
Cyclooxygenase Inhibitors
;
Interferons/*pharmacology
;
Leukemia L1210
;
Lipoxygenase/metabolism
;
Lipoxygenase Inhibitors
;
Mice
;
Prostaglandin-Endoperoxide Synthases/*deficiency
;
Prostaglandins/biosynthesis
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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