Publication Date:
2013-09-21
Description:
Circadian clocks are self-sustained cellular oscillators that synchronize oxidative and reductive cycles in anticipation of the solar cycle. We found that the clock transcription feedback loop produces cycles of nicotinamide adenine dinucleotide (NAD(+)) biosynthesis, adenosine triphosphate production, and mitochondrial respiration through modulation of mitochondrial protein acetylation to synchronize oxidative metabolic pathways with the 24-hour fasting and feeding cycle. Circadian control of the activity of the NAD(+)-dependent deacetylase sirtuin 3 (SIRT3) generated rhythms in the acetylation and activity of oxidative enzymes and respiration in isolated mitochondria, and NAD(+) supplementation restored protein deacetylation and enhanced oxygen consumption in circadian mutant mice. Thus, circadian control of NAD(+) bioavailability modulates mitochondrial oxidative function and organismal metabolism across the daily cycles of fasting and feeding.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963134/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963134/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Peek, Clara Bien -- Affinati, Alison H -- Ramsey, Kathryn Moynihan -- Kuo, Hsin-Yu -- Yu, Wei -- Sena, Laura A -- Ilkayeva, Olga -- Marcheva, Biliana -- Kobayashi, Yumiko -- Omura, Chiaki -- Levine, Daniel C -- Bacsik, David J -- Gius, David -- Newgard, Christopher B -- Goetzman, Eric -- Chandel, Navdeep S -- Denu, John M -- Mrksich, Milan -- Bass, Joseph -- 5P01HL071643-10/HL/NHLBI NIH HHS/ -- 5P30AR057216-05/AR/NIAMS NIH HHS/ -- F30 DK085936/DK/NIDDK NIH HHS/ -- F30 ES019815/ES/NIEHS NIH HHS/ -- F32 DK092034/DK/NIDDK NIH HHS/ -- P01 AG011412/AG/NIA NIH HHS/ -- P01AG011412-16/AG/NIA NIH HHS/ -- P01DK58398/DK/NIDDK NIH HHS/ -- P30 CA014520/CA/NCI NIH HHS/ -- R01 AG038679/AG/NIA NIH HHS/ -- R01 CA152601-01/CA/NCI NIH HHS/ -- R01 CA152799-01A1/CA/NCI NIH HHS/ -- R01 CA16383801A1/CA/NCI NIH HHS/ -- R01 CA168292/CA/NCI NIH HHS/ -- R01 CA168292-01A1/CA/NCI NIH HHS/ -- R01 DK090242/DK/NIDDK NIH HHS/ -- R01 DK090625/DK/NIDDK NIH HHS/ -- R01 GM065386/GM/NIGMS NIH HHS/ -- R01 HL097817/HL/NHLBI NIH HHS/ -- R01DK090242-03/DK/NIDDK NIH HHS/ -- R01DK090625-01A1/DK/NIDDK NIH HHS/ -- R01HL097817-01/HL/NHLBI NIH HHS/ -- R37 GM059785/GM/NIGMS NIH HHS/ -- T32 DK007169/DK/NIDDK NIH HHS/ -- T32 GM008152/GM/NIGMS NIH HHS/ -- T32 HL007909/HL/NHLBI NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2013 Nov 1;342(6158):1243417. doi: 10.1126/science.1243417. Epub 2013 Sep 19.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24051248" target="_blank"〉PubMed〈/a〉
Keywords:
ARNTL Transcription Factors/genetics/metabolism
;
Acetylation
;
Animals
;
Circadian Clocks/genetics/*physiology
;
*Energy Metabolism
;
Fasting
;
Lipid Metabolism
;
Liver/metabolism
;
Mice
;
Mice, Knockout
;
Mitochondria, Liver/*metabolism
;
NAD/*metabolism
;
Oxidation-Reduction
;
Oxygen Consumption
;
Sirtuin 3/genetics/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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