Publication Date:
2012-03-17
Description:
To study the evolution of recombination rates in apes, we developed methodology to construct a fine-scale genetic map from high-throughput sequence data from 10 Western chimpanzees, Pan troglodytes verus. Compared to the human genetic map, broad-scale recombination rates tend to be conserved, but with exceptions, particularly in regions of chromosomal rearrangements and around the site of ancestral fusion in human chromosome 2. At fine scales, chimpanzee recombination is dominated by hotspots, which show no overlap with those of humans even though rates are similarly elevated around CpG islands and decreased within genes. The hotspot-specifying protein PRDM9 shows extensive variation among Western chimpanzees, and there is little evidence that any sequence motifs are enriched in hotspots. The contrasting locations of hotspots provide a natural experiment, which demonstrates the impact of recombination on base composition.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532813/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532813/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Auton, Adam -- Fledel-Alon, Adi -- Pfeifer, Susanne -- Venn, Oliver -- Segurel, Laure -- Street, Teresa -- Leffler, Ellen M -- Bowden, Rory -- Aneas, Ivy -- Broxholme, John -- Humburg, Peter -- Iqbal, Zamin -- Lunter, Gerton -- Maller, Julian -- Hernandez, Ryan D -- Melton, Cord -- Venkat, Aarti -- Nobrega, Marcelo A -- Bontrop, Ronald -- Myers, Simon -- Donnelly, Peter -- Przeworski, Molly -- McVean, Gil -- 076113/E/04/Z/Wellcome Trust/United Kingdom -- 086084/Wellcome Trust/United Kingdom -- 086084/Z/08/Z/Wellcome Trust/United Kingdom -- 086786/Z/08/Z/Wellcome Trust/United Kingdom -- 090532/Wellcome Trust/United Kingdom -- 090532/Z/09/Z/Wellcome Trust/United Kingdom -- R01 GM083098/GM/NIGMS NIH HHS/ -- R01 GM83098/GM/NIGMS NIH HHS/ -- R01 HG004428/HG/NHGRI NIH HHS/ -- T32 GM007197/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2012 Apr 13;336(6078):193-8. doi: 10.1126/science.1216872. Epub 2012 Mar 15.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wellcome Trust Centre for Human Genetics, Oxford , UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22422862" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Base Sequence
;
Chromosome Mapping
;
Chromosomes, Human, Pair 2/genetics
;
Chromosomes, Mammalian/*genetics
;
CpG Islands
;
Evolution, Molecular
;
Female
;
Genetic Variation
;
Haplotypes
;
High-Throughput Nucleotide Sequencing
;
Histone-Lysine N-Methyltransferase/genetics
;
Humans
;
Male
;
Pan troglodytes/*genetics
;
Polymorphism, Single Nucleotide
;
*Recombination, Genetic
;
Sequence Analysis, DNA
;
Species Specificity
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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