Publication Date:
1986-02-14
Description:
Examination of the histocompatibility region of the nonobese diabetic (NOD) mouse with antibodies against class II glycoproteins (products of immune response genes of the major histocompatibility complex I-A and I-E), hybrid T-cell clones, and mixed-lymphocyte cultures and analysis of restriction fragment length polymorphisms indicate that the NOD mouse has a unique class II major histocompatibility complex with no expression of surface I-E, no messenger RNA for I-E alpha, and an I-A not recognized by any monoclonal antibodies or hybrid T-cell clones studied. In crosses of NOD mice with control C3H mice, the development of diabetes was dependent on homozygosity for the NOD mouse's unique major histocompatibility region.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hattori, M -- Buse, J B -- Jackson, R A -- Glimcher, L -- Dorf, M E -- Minami, M -- Makino, S -- Moriwaki, K -- Kuzuya, H -- Imura, H -- AM07009-01/AM/NIADDK NIH HHS/ -- AM32083-03/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1986 Feb 14;231(4739):733-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3003909" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Chromosome Mapping
;
DNA Restriction Enzymes/metabolism
;
Diabetes Mellitus, Type 1/*genetics
;
Genes, Recessive
;
Genetic Linkage
;
Genotype
;
H-2 Antigens/genetics
;
Histocompatibility Antigens Class II/*genetics
;
Interleukin-2/biosynthesis
;
*Major Histocompatibility Complex
;
Mice
;
Mice, Mutant Strains/*genetics
;
Spleen/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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