Publication Date:
1995-06-30
Description:
The molecular defects responsible for tumor cell hypermutability in humans have not yet been fully identified. Here the gene encoding a G/T mismatch-binding protein (GTBP) was localized to within 1 megabase of the related hMSH2 gene on chromosome 2 and was found to be inactivated in three hypermutable cell lines. Unlike cells defective in other mismatch repair genes, which display widespread alterations in mononucleotide, dinucleotide, and other simple repeated sequences, the GTBP-deficient cells showed alterations primarily in mononucleotide tracts. These results suggest that GTBP is important for maintaining the integrity of the human genome and document molecular defects accounting for variation in mutator phenotype.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Papadopoulos, N -- Nicolaides, N C -- Liu, B -- Parsons, R -- Lengauer, C -- Palombo, F -- D'Arrigo, A -- Markowitz, S -- Willson, J K -- Kinzler, K W -- CA35494/CA/NCI NIH HHS/ -- CA47527/CA/NCI NIH HHS/ -- CA62924/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1995 Jun 30;268(5219):1915-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Johns Hopkins Oncology Center, Baltimore, MD 21231, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7604266" target="_blank"〉PubMed〈/a〉
Keywords:
Base Sequence
;
Chromosome Mapping
;
Chromosomes, Human, Pair 2
;
Codon
;
Colorectal Neoplasms/*genetics
;
Colorectal Neoplasms, Hereditary Nonpolyposis/genetics
;
DNA Repair/*genetics
;
DNA, Neoplasm/*genetics
;
DNA, Satellite/genetics
;
DNA-Binding Proteins/*genetics
;
*Frameshift Mutation
;
Genetic Markers
;
Germ-Line Mutation
;
Humans
;
Molecular Sequence Data
;
Tumor Cells, Cultured
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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