ISSN:
1573-5117
Keywords:
phospholipase A2 inhibitors
;
marine algae
;
marine secondary metabolites
;
Rhodophyta
;
Phaeophyta
;
Chlorophyta
;
marine natural products
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract Twelve out of twenty-nine compounds isolated from benthic marine algae from the phyla Chlorophyta, Phaeophyta and Rhodophyta have been found to be potent inhibitors of bee venom derived phospholipase A2 (PLA2) (〉 50%) in the μM range. The compounds investigated were from: Bryopsis pennata, Rhipocephalus phoenix, Caulerpa prolifera, C. racemosa, C. bikinensis, Cymopolia barbata, Laurencia cf. palisada, Laurencia sp., Ochtodes crockeri, Liagora farinosa, Sphaerococcus coronipifolius, Phacelocarpus labillardieri, Dictyota sp., B furcaria galapagensis, Stypopodium zonale, Dictyopteris undulata, Stoechospermum marginatum, Dictyopteris divaricata, Dilophus fasciola and Dilophus sp. This is the first report of bee venom PLA2 inhibition in vitro by pure compounds isolated from marine algae.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00049065
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