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  • 1
    Electronic Resource
    Electronic Resource
    Structural versatility of peptides from Cα,αdialkylated glycines: Linear Ac3c homo-oligopeptides (1989)
    New York : Wiley-Blackwell
    Biopolymers 28 (1989), S. 175-184 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The crystal-state molecular structures of five linear Ac3c homo-oligopeptides to the tetramer were determined by x-ray diffraction. The oligomers are H-(Ac3c)2-OMe, Fmoc-(Ac3c)2-OMe MeOH, Ac-(Ac3c)2-OMe, pBrBz-(Ac3c)3-OMe · H2O, and t-Boc-(Ac3c)4-OMe · 2H2O. The results indicate the propensity of the tri- and tetrapeptides to fold into type I β-bends and distorted 310-helices, respectively, in partial contrast to Aib, Ac5c, and Ac6c homo-peptides of comparable main-chain length, where regular type III β-bends and 310-helical structures were found. When the influence of the constraints produced by the intramolecular H bonds of the C10-type is absent, other less common structural features may be observed. The average geometry of the cyclopropyl group of the Ac3c residue is found to be asymmetric and the N—Cα—C′ bond angle significantly expanded from the regular tetrahedral value.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.360280119
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  • 2
    Electronic Resource
    Electronic Resource
    Synthesis and antinociceptive activity of peptides related to interleukin-1β193-195 Lys-Pro-Thr (1996)
    New York : Wiley-Blackwell
    Biopolymers 40 (1996), S. 479-484 
    Details
    ISSN: 0006-3525
    Keywords: structure-activity relationships ; analgesic peptides ; antinociceptive activity ; interleukin-1β193-195 ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: To obtain information about the structure-activity relationships of analgesic peptides, we modified the previously reported tripeptide, H-Lys-Pro-Thr-OH (C). The proline part in C was replaced with various analogues of unconventional amino acids {(3aS, 7aS)-octahydroindole-2-carboxylic acid (Oic), (S,S,S,)-2-azabiciclo [3.3.0] octane-3-carboxylic acid (Aoc), D-Aoc, and (2S, 4R)-hydroxyproline (Hyp)} with varying lipophilic, steric, and conformational properties, and alternatively with Lys and Orn in the lysine part. Moreover, the threonine part was changed to various natural amino acids (Ser, Thr, Val, Leu). All the compounds were screened in vivo for their analgesic effects in mouse writhing test. Compound 24 (H-Orn-Hyp-Val-OH), the most active compound within the series, showed an ED50 value of 10 mg/kg, which is comparable with the ED50 values exhibited by indometacin (4.1 mg/kg) and the dipeptide H-Lys-D-Pro-OH (6.9 mg/kg), both used as reference drugs. © 1997 John Wiley & Son's, Inc. Biopoly 40: 479-484, 1996
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Preferred conformation of peptides rich in alicyclic Cα,α-disubstituted glycines (1996)
    New York : Wiley-Blackwell
    Biopolymers 40 (1996), S. 519-522 
    Details
    ISSN: 0006-3525
    Keywords: conformational analysis, of peptides ; disubstituted glycines, peptides rich in ; Fourier transform ir absorption, of peptides ; 310-helical conformation, in peptides ; Cα-methylated α-amino acids, peptides rich in ; nmr, of peptides ; peptide conformation ; x-ray diffraction, of peptides ; β-turn conformation, in peptides ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The conformational preferences of the alicyclic Cα,α-disubstituted glycines Acnc (1-amino-1-cycloalkane-carboxylic acid; n = 4, 7, 9, 12) were assessed in selected model compounds, including homopeptides and Ala (or Aib, α-aminoisobutyric acid)/Acnc peptides containing a small total number of residues, by Fourier transform ir absorption, 1H-nmr, and x-ray diffraction analyses. The results obtained indicate that β-turn and 310-helical structures are preferentially adopted by short peptides rich in these cycloaliphatic α-amino acids. © 1997 John Wiley & Sons, Inc. Biopoly 40: 519-522, 1996
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Synthesis and biological activity of tripeptide FR113680 analogues containing unconventional amino acidsSymbols and abbrevations are in accord with recommendations from Ref. 1. (1995)
    New York : Wiley-Blackwell
    Biopolymers 36 (1995), S. 409-414 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: In order to further develop structure-activity relationships and to get information about the biological active conformations we synthetized analogues tripeptide to the FR 113680 [Ac- Thr-D-Trp(CHO)-PheNMeBzl; Ac: acethyl], in which the phenylalanine residue was replaced by unconventional amino acids [1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic); (3aS, 7aS)-octahydroindole-2-carboxylic acid (Oic); (S,S,S)-2-azabiciclo[3.3.0]octane-3-carboxylic acid (Aoc); 3-(1′-naphthyl) alanine (Nap) phenylglicine (Phg); thienylalanine (Thi)]. The biological activity of the peptides was performed on guinea pig ileumfar neurokinin 1 (NK-1) and on rat colon for neurokinin 2 (NK-2). In particular, the replacement of the Phe3 by the Oic (8a) gave an higher antagonist activity in both NK-1 and NK-2 receptors, but no improvement in selectivity with respect to reference tripeptide (FR113680) The compound (8a) represent the first example of highly potent peptides that do not contain an aromatic mi no acid of the third position as had been previously considered essential. © 1995 John Wiley & Sons, Inc.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.360360404
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