ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Ingestion of yellow star thistle (Centaurea solstitialis L.) by horses produces parkinsonism due to nigro-pallidal degeneration. The toxin responsible has not been identified so far. A CH2Cl2 extract from the aerial parts of C. solstitialis exhibited significant neurotoxicity against primary neuronal cultures of foetal rat brain. Activity-guided fractionation yielded the known sesquiterpene lactones solstitialin A (1), 13-0-acetylsolstitialin A (3), cynaropicrin (4), and the hitherto unknown 3-O-acetylsolstitialin A (2). In the bioassay with rat foetal full cell culture, 3 and 4 were toxic in a concentration-dependent manner and may be responsible for the ability of the plant to cause neurodegenerative changes in the brain of horses.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19910740114
Permalink