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  • 1
    Electronic Resource
    Electronic Resource
    Separation of enantiomers of drugs by capillary electrophoresis, part 7: Gamma-cyclodextrin as chiral solvating agent (1998)
    New York, NY [u.a.] : Wiley-Blackwell
    Chirality 10 (1998), S. 548-554 
    Details
    ISSN: 0899-0042
    Keywords: capillary electrophoresis ; enantiomer separation ; chiral drugs ; γ-cyclodextrin ; gamma-cylcodextrin ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Following an extended chiral drug screening program by capillary zone electrophoresis (CZE), the enantioseparation of 86 racemic drugs was tested with γ-cyclodextrin as a chiral solvating agent. Unified conditions were applied to all experiments. In total, 18 drug racemates were separated, 13 entries thereof that had not been separated at the lower CSA concentration applied in an earlier stage of the project. A comparison of the data with the results obtained for α- and β-cyclodextrin points to the significance of partial penetration (“side-on binding”) of aryl groups into the cyclodextrin cavity. Chirality 10:548-554, 1998. © 1998 Wiley-Liss, Inc.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Separation of Enantiomers of Drugs by Capillary Electrophoresis, Part 6. Hydroxypropyl-β-cyclodextrin as Chiral Solvating Agent (1998)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 21 (1998), S. 215-224 
    Details
    ISSN: 0935-6304
    Keywords: capillary electrophoresis ; enantiomer separation ; hydroxypropyl-β-cyclodextrin ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---Following an extended screening project, 86 racemic drugs were investigated by capillary zone electrophoresis in the presence of the chiral solvating agent (CSA) hydroxypropyl-β-cyclodextrin. A total of 42 drugs out of 86 tested was thereby separated into enantiomeric pairs. Statistical analysis of the numerous experiments performed un der identical conditions reveals a loose correlation of the migration separation factor (αm) with the migration retardation factor (Rm). For a subset of 23 drugs, a drop in the concentration of the CSA was also studied, showing the way to further optimization.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Optimization and identification in any kind of multi-step temperature programmed gas chromatography (1986)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 9 (1986), S. 702-707 
    Details
    ISSN: 0935-6304
    Keywords: Gas chromatography ; Temperature programming ; Optimization ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The theory which predicts the retention time, retention temperature, and peak width for any kind of multi-step TPGC and the principle of optimization has been described. Software for optimization and identification in TPGC has been developed on the basis of this theory. It has also been proven that the relationship between peak width in TPGC and the derived or “invented” retention time is similar to that between peak width and retention time in isothermal processes. The validity of the software has been proved by using it to predict retention temperature, retention time, and peak width for any kind of temperature programming and to predict the optimum temperature program for separation of a multihomolog mixture of industrial alcohols and 15 enantiomeric pairs of amino acids.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240091123
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  • 4
    Electronic Resource
    Electronic Resource
    Separation of enantiomers of drugs by capillary electrophoresis. Part 4: Hydroxyprpyl-gammacyclodextrin as chiral solvating agent (1997)
    Weinheim : Wiley-Blackwell
    Electrophoresis 18 (1997), S. 924-930 
    Details
    ISSN: 0173-0835
    Keywords: Capillary electrophoresis ; Enantiomer separation ; Chiral drugs ; Hydroxypropyl-γ-cyclodextrin ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: In an extended chiral drug screening program, enantioseparation of 86 racemic drugs was tested with hydroxypropyl-γ-cyclodextrin as chiral solvating agent (CSA). A total of 30 drugs out of 86 could be resolved in this straightforward approach. The number of experiments performed under identical conditions allows a statistical treatment of the data. The enantioseparation of the analytes is correlated with their interaction strength with the CSA. Hence, the concentration of the CSA is a crucial parameter for optimization of the enantioseparation, as shown by a subset of 23 examples.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elps.1150180612
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