ISSN:
1075-4261
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Biology
,
Physics
Notes:
Polarized Raman scattering measurements have been made of a single crystal of AZT (3′-azido-3′-deoxythymidine) by the use of a Raman microscope with the 488.0 nm exciting beam from an argon-ion laser. The AZT crystal belongs to the space group P21 (monoclinic), and Raman scattering intensities, corresponding to the aa, bb, c′c′, and bc′ components of the crystal Raman tensor, have been determined for each prominent Raman band. Here, c′-axis was defined as an axis perpendicular to the a-axis in the ac plane. From these experimental data, and on the basis of the known crystal structure, localized Raman tensors have been determined, which are assignable to azido vibrations at 2088 and 1259 cm-1, to thymine at 1666, 1392, 1238, 771, and 495 cm-1 and deoxyribose vibrations at 870, 849 and 739 cm-1. The knowledge of these localized Raman tensors are considered to be useful for probing the orientation of the AZT molecule in a biological system involving it. © 1996 John Wiley & Sons, Inc.
Additional Material:
7 Ill.
Type of Medium:
Electronic Resource
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