ALBERT — All Library Books, journals and Electronic Records Telegrafenberg

Hits per page

hits 1 - 2 | 2 hits

Sorting

Electronic Resource

Pranidipine, a new 1, 4-dihydropyridine calcium channel blocker, enhances cyclic GMP-independent nitric oxide-induced relaxation of the rat aorta (1998)

Mori, Toyoki ; Takeuchi, Tadayoshi ; Ohura, Makoto ; [et al.]

Springer

Molecular and cellular biochemistry 178 (1998), S. 335-343

add to mindlist on the mindlist

Details

ISSN: 1573-4919

Keywords: NO-induced relaxation ; rat aorta ; cyclic GMP-independent relaxation ; pranidipine ; calcium channel blocker

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Chemistry and Pharmacology , Medicine

Notes: Abstract Pranidipine, a new calcium channel modulator, prolonged endothelium-dependent relaxation induced by acetylcholine in a aortic ring preparation, contracted with prostaglandin F2α. This action was not shared by amlodipine. The effect was not modified by indomethacin, suggesting that the action of pranidipine does not involve prostanoid metabolism. NG-nitro-L-arginine completely prevented the action of Pranidipine. The drug affected neither nitric oxide (NO) synthase activity nor the level of cyclic GMP in the vessel. Pranidipine did not affect the sensitivity of the contractile proteins to calcium. Pranidipine also did not alter cyclic GMP-induced relaxation in a-toxinskinned vascular preparations. Pranidipine also prolonged glyceryl trinitrate-induced relaxation in the endothelium denuded rat aorta. Furthermore, pranidipine enhanced relaxation of the aorta induced by glyceryl trinitrate even in the presence of methylene blue, a guanylyl cyclase inhibitor. This action was not modified by iberiotoxin or by charybdotoxin, two inhibitors of the calciumactivated potassium channel. The results strongly suggest that pranidipine enhances cyclic GMPindependent NO-induced relaxation of smooth muscle by a mechanism other than through NOinduced hyperpolarization. These effects were in direct contrast to amlodipine, another new 1,4dihydropyridine calcium antagonist.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1023/A:1006827801386

Permalink

	Location	Call Number	Expected	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

Electronic Resource

The mechanism of anionic polymerization of dimethylketene (1967)

Yoshida, Kenji ; Yamashita, Yuya

New York : Wiley-Blackwell

Die Makromolekulare Chemie 100 (1967), S. 175-185

add to mindlist on the mindlist

Details

ISSN: 0025-116X

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Physics

Description / Table of Contents: Bei der Reaktion von Dimethylketen mit GRIGNARD-Reagenz in Äther werden Oligomere mit Polyketonstruktur gebildet. Der nicht destillierbare Anteil besitzt Polyesterstruktur. Daraus wird geschlossen, daß die Polyketonbildung langsam abläuft, während die Polyesterbildung eine schnelle Reaktion ist.Aus Fraktionierungsergebnissen an Polymeren, die unter verschiedenen Bedingungen hergestellt wurden, wird abgeleitet, daß drei Arten von wachsenden Ketten im dynamischen Gleichgewicht für den Polymerisationsmechanismus bestimmend sind.

Notes: In the reaction of dimethylketene with GRIGNARD reagent of ether polyketonic type oligomers were formed, but the non-distillable fraction was of polyester type. Therefore it is suggested that the propagation reaction to polyketone proceeds slowly, but those to polyester is a fast one.From the results of fractionations of polymers prepared under various conditions, the polymerization mechanism is explained by three kinds of growing chain ends which are in dynamic equilibrium.

Additional Material: 1 Ill.