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  • 1
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    The paucity of grants among young scientists (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-12-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Campbell, Peter -- New York, N.Y. -- Science. 2002 Dec 20;298(5602):2328-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12498168" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Science Disciplines/*education ; *Education, Graduate ; Great Britain ; Time Factors ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Statement on scientific publication and security (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-02-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Atlas, Ronald -- Campbell, Philip -- Cozzarelli, Nicholas R -- Curfman, Greg -- Enquist, Lynn -- Fink, Gerald -- Flanagin, Annette -- Fletcher, Jacqueline -- George, Elizabeth -- Hammes, Gordon -- Heyman, David -- Inglesby, Thomas -- Kaplan, Samuel -- Kennedy, Donald -- Krug, Judith -- Levinson, Rachel -- Marcus, Emilie -- Metzger, Henry -- Morse, Stephen S -- O'Brien, Alison -- Onderdonk, Andrew -- Poste, George -- Renault, Beatrice -- Rich, Robert -- Rosengard, Ariella -- Salzburg, Steven -- Scanlan, Mary -- Shenk, Thomas -- Tabor, Herbert -- Varmus, Harold -- Wimmer, Eckard -- Yamamoto, Keith -- Journal Editors and Authors Group -- New York, N.Y. -- Science. 2003 Feb 21;299(5610):1149.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12595658" target="_blank"〉PubMed〈/a〉
    Keywords: *Access to Information ; *Bioterrorism ; Peer Review, Research ; Periodicals as Topic ; *Publishing ; *Security Measures ; *Terrorism ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Data analysis: Create a cloud commons (2015)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2015-07-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stein, Lincoln D -- Knoppers, Bartha M -- Campbell, Peter -- Getz, Gad -- Korbel, Jan O -- England -- Nature. 2015 Jul 9;523(7559):149-51. doi: 10.1038/523149a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Ontario Institute of Cancer Research, Toronto, Canada. ; Centre of Genomics and Policy, McGill University, Montreal, Canada. ; Wellcome Trust Sanger Institute, Hinxton, UK. ; Cancer Genome Computational Analysis group at the Broad Institute of MIT and Harvard, Cambridge, Massachusetts, and is the director of bioinformatics in the Cancer Center and Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA. ; European Molecular Biology Laboratory, Heidelberg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26156357" target="_blank"〉PubMed〈/a〉
    Keywords: *Access to Information ; Databases, Genetic/economics/standards/trends ; Information Storage and Retrieval/economics/standards/*trends ; National Institutes of Health (U.S.) ; United States
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 4
    Electronic Resource
    Electronic Resource
    Scopolamine permation through human skin in vitro (1976)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 22 (1976), S. 828-832 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The sorption and rate of permeation of scopolamine base in human skin have been measured as a function of drug concentration in aqueous solution contacting the stratum corneum surface of the skin. The sorption isotherm is nonlinear, and the apparent penetrant diffusivity computed from steady state permeation data is greater than that estimated from unsteady state (time lag) measurements.By assuming that sorption occurs by both ordinary dissolution and binding of penetrant to immobile sites in the membrane, the experimental sorption isotherm can be predicted, and the disparity between steady state and time lag diffusivities can be reconciled.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690220503
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of dimethyl sulfoxide on drug permeation through human skin (1977)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 23 (1977), S. 810-816 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The effect of the presence of dimethyl sulfoxide (in admixture with water) on the sorption and permeation rate of scopolamine base in human skin in vitro has been measured as a function of drug concentration in aqueous solution. The equilibrium sorption of scopolamine by skin from solution appears to be unaffected by the presence of even high concentrations of dimethyl sulfoxide in the solution phase. In the absence of a transdermal gradient of DMSO (or water), the permeability of skin to scopolamine in the presence of DMSO is about twofold higher than in its absence, suggesting that the diffusivity of scopolamine in the stratum corneum is somewhat elevated by the solvating action of DMSO.When, however, a gradient of DMSO concentration is impressed across the skin (irrespective of whether that gradient is of the same or opposite sign to that of the drug), the permeability of the skin to scopolamine is increased by one to two orders of magnitude. Microscopic examination of the skin subjected to such treatment reveals marked swelling, distortion, and intercellular delamination of the stratum corneum, which is only partially reversible following complete extraction with water. These effects are believed due to development of very high osmotic stresses produced within the stratum corneum, as both water and DMSO are transported into the tissue.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690230606
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  • 6
    Electronic Resource
    Electronic Resource
    Application of the ‘dual sorption’ model to drug transport through skin (1980)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 20 (1980), S. 36-39 
    Details
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The dual sorption theory has been extended to the transport of drug molecules through human skin in vitro. By assuming that sorption of drug molecules occurs by both dissolution and binding of drug to immobile sites in the skin, the experimental sorption isotherm can be predicted, and the disparity between steady state and time lag diffusivities can be reconciled. Furthermore, the dual sorption model has been used to develop techniques for controlling these sorption transport processes in order to rapidly achieve predictable transdermal drug delivery in vivo.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pen.760200107
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  • 7
    Electronic Resource
    Electronic Resource
    Isolation of predominantly submicron-sized UHMWPE wear particles from periprosthetic tissues (1995)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 29 (1995), S. 127-131 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: A method of tissue digestion using sodium hydroxide was applied to the isolation and recovery of ultra-high-molecular-weight polyethylene (UHMWPE) particles from tissues around failed total hip replacements. Density gradient ultracentrifugation of the digested tissues was performed to separate the UHMWPE from cell debris and other particulates. Fourier transform infrared spectroscopy and differential scanning calorimetry (DSC) verified that the recovered particles were UHMWPE. When viewed by scaning electron microscopy, individual particles were clearly observed and were either rounded or elongated. The majority were submicron in size. The application of this method to the study or particles from periprosthetic tissues may elucidate aspects of biomaterial particles size and shape that are important to the biologic response to, and clinical outcome of, total joint replacement. © 1995 John wiley & Sons, Inc.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820290118
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